SKU: 43378377808

Nucleoskin Topic 5x3ml Promoitalia

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Description

Nucleoskin Topic 5x3ml PromoitaliaPromoitalia NUCLEOSKIN TOPIC Use by date 03 2024 Promoitalia NUCLEOSKIN TOPIC the power of PDRN Polynucleotides combined with the efficacy of Hyaluronic Acid. The new products that contain highly purified Polynucleotidic matrices are able to activate processes of skin bio regeneration both at the deep level (adipose and bone tissue), and at the level of dermis (fibroblastic stimulation). BENEFITS: Skin lifting effect Biorestructuring of the deep

Promoitalia NUCLEOSKIN TOPIC

Use by date 03/2024

Promoitalia NUCLEOSKIN TOPIC – the power of  PDRN – Polynucleotides combined with the efficacy of Hyaluronic Acid.

The new products that contain highly purified Polynucleotidic matrices are able to activate processes of skin bio-regeneration both at the deep level (adipose and bone tissue), and at the level of dermis (fibroblastic stimulation).

BENEFITS:

  • Skin lifting effect
  • Biorestructuring of the deep dermis
  • Moisturizing action
  • Improve the look of small depressed scars and of periocular wrinkles
  • Highly indicated pre-and post-surgical treatments (Blepharoplasty, lifting, resurfacing laser
  • Liquid lifting
    PDRNs work by stimulating rejuvenation processes and toning tissues.
  • Filler effect
    Hyaluronic acid reduces the appearance of skin blemishes such as wrinkles and skin depressions.
  • Antioxidant
    Glutathione defends the skin from free radicals’ attack and restores the correct amount of acetyl cysteine for proper cellular defence.

Application technique and protocol

  • Nucleoskin can be applied using either the dermapen or a dermaroller.
  • The intensity of the treatment, the depth of the needles, must be calibrated according to the type of skin and the characteristics of the patient.
  • The application through Hyaluron Pen is also indicated, in this case we do not recommend treatment in the vermilion area.
  • 1-2 ml of product are usually required to treat the facial area.
  • The treatment must be repeated every 20-25 days for a minimum of 4 sessions.

Protocol for face and body

  • Normally we need 1.5 ml for face, using 0.025 ml of product for each application (about 60 micro applications for the whole face).
  • For body the quantities are necessarily higher: 3ml for each session with 0.1 ml per application.
  • We recommend 4/6 session, one every 20 days.

Protocol for periocular area

  • The periocular area is much more delicate and for this reason the product must be diluted with physiological solution with ratio 1:1 (1 ml of product + 1 ml of physiological solution). In this case we need about 0,025 ml for single application.
  • We recommend 3/4 session, one every 28 days.

KEY INGREDIENTS:

  • Biologically-derived PDRN with high molecular weight (2500KD) 2%
  • Hyaluronic Acid 10 mg/ml crosslinked with BDDE
  • Glutathione 2 mg/ml

Polynucleotides (PDRN) – Polydeoxyribonucleotides, or PDRNs, are the molecules that make up our DNA, our genetic code, which is why they are very precious molecules for the body and cells. Stimulates cellular receptors and the maturation of fibroblasts in myofibroblasts.

Their main feature, in addition to transmitting genetic information, is that of being able to activate many cells membrane receptors and trigger biological processes that are fundamental for the life of the cells themselves.

Hyaluronic acid – is a molecule naturally present in our body and is produced by fibroblast, cells that have the aim of moisturizing the tissue, giving them firmness and plasticity. Hyaluronic acid absorbs water, retains, and releases it according to the needs of the body and, therefore, maintains the right hydration and moisture of the tissues.

Glutathione – is an antioxidant found in plants, animals, fungi, and in some bacteria. It can prevent damage of important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals. It may also affect skin pigmentation by inhibiting tyrosinase activity during melanogenesis, either directly or indirectly.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 43378377808

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4.5 ★★★★★
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Denise
Lowell, US
★★★★★ 5
Kid and mom and dental professional approves. P.S get the floss too.
My toddler loves this toothpaste. He gets so excited when he sees me load up his toothbrush for the evening. I like that it is fluoride free so I don’t have to worry about him eating it. Because he will, because he is 16 months old. I love that it still has the remineralizing component (anti-cavity, strong enamel) of the nano-hydroxyapatite. As a dental hygienist (and mom) this is important to me. Personally… the vanilla cardamom is not my favorite flavor. I wanted to try out the limited edition and I like cardamom (just not in toothpaste apparently) However, my son loves it! Boka has lots of different flavors I’m sure we will try over time. I’m sure I will find one I like better. P.S Boka floss is amazing. I recommend it to many of my patients, and I use it at home.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 24, 2026
M
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Miss Havisham
West Palm Beach, US
★★★★★ 3
Torn About Whether to Keep Using
I bought the Vanilla Cardamon flavor, because I'm allergic to mint, and it makes my mouth swell. It tastes nice. The "flavor" doesn't last a long time, so you don't necessarily get that fresh breath feeling. The toothpaste works fine. There seems to be some controversy over whether Nano Hydroxyapatite Toothpaste really protects teeth as well as fluoride, but I know some people swear by it. Obviously, there is also lot of controversy regarding fluoride and whether it's healthy, so I get why this might be a better option for some. I've been using it for about a year, and I got a fairly bad cavity recently, but of course, this is just anecdotal evidence. I'm not sure whether I'll keep using it or not.
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Reviewed in the United States on December 13, 2025
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Verified Purchase
Mina
Waukegan, US
★★★★★ 5
Great for sensitive teeth
Size: Pack of 3, 4 Ounce, Set name: E. Ela Mint, Coco Ginger, Lemon Lavender
If you have sensitive teeth, these are great. I had prescription toothpaste and couldn’t get it anymore and picked this up. It’s helped tremendously. No different than normal toothpaste consistency-wise but the flavors are the best.
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Reviewed in the United States on April 11, 2026
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DAVID
Carnegie, US
★★★★★ 5
Truly works and worth every penny.
Size: Pack of 3, 4 Ounce, Set name: E. Ela Mint, Coco Ginger, Lemon Lavender
This is a game changer. All other toothpastes should pack up and close shop. I don’t know what I Was using before, but it was not toothpaste. This is the only toothpaste you should be using.
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Reviewed in the United States on May 28, 2026
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Javier Villegas
Fort Morgan, US
★★★★★ 5
Delicious and a great way to get vitamin C
Flavor Name: Natural Fruit, Size: 8 Ounce (1 Pack)
Love these! Super good. Wish they had a bucket of 'em to sell too, not just bags. I'd buy one in an instant
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Reviewed in the United States on May 16, 2026

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