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Description
CYP17A1 Recombinant Rabbit mAb (S-1961-49)Product Specification Host Rabbit Antigen CYP17A1 Synonyms Steroid 17 alpha hydroxylase 17,20 lyase; 17 alpha hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 C17 (Cytochrome P450c17); Steroid 17 alpha monooxygenase; CYP17; S17AH Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession P05093 Clone Number S 1961 49 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample A549, HeLa,
Product Specification
| Host | Rabbit |
| Antigen | CYP17A1 |
| Synonyms | Steroid 17-alpha-hydroxylase/17,20 lyase; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17 (Cytochrome P450c17); Steroid 17-alpha-monooxygenase; CYP17; S17AH |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | P05093 |
| Clone Number | S-1961-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | A549, HeLa, Jurkat, SK-OV-3, HepG2 |
| Predicted Reactivity | Bb, CyMk, Cz |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Cytochrome P450 17A1 (CYP17A1) is a critical enzyme in human steroidogenesis, responsible for producing essential hormones such as glucocorticoids, androgens, and estrogens. It is a dual-function monooxygenase with both 17α-hydroxylase and 17,20-lyase activities. The 17α-hydroxylase activity converts pregnenolone to 17α-hydroxypregnenolone, while the 17,20-lyase activity cleaves carbon-carbon bonds to produce androgens like dehydroepiandrosterone (DHEA). CYP17A1 is located on chromosome 10q24.3 and is a member of the cytochrome P450 superfamily, which are known for their role in catalyzing various metabolic processes. Mutations in the CYP17A1 gene can lead to disorders such as congenital adrenal hyperplasia and sex development abnormalities due to impaired steroid hormone synthesis. Additionally, CYP17A1 is a therapeutic target in prostate cancer treatment, as it plays a role in androgen synthesis, which can drive cancer growth.
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