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Description
Histone H3 (acetyl K23) Recombinant Rabbit mAb (S-3321-202)Product Specification Host Rabbit Antigen Histone H3 (acetyl K23) Synonyms H3K23ac Immunogen Synthetic Peptide Location Nucleus Accession P68431 Clone Number S 3321 202 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample MCF7 (treated with 50 mM sodium butyrate for 24 hours and 500 ng ml TSA for 4 hours), NIH 3T3 (treated with 500 ng ml TSA for 4 hours), C6 (treated with 500 ng ml TSA for 4
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 (acetyl K23) |
| Synonyms | H3K23ac |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-3321-202 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | MCF7 (treated with 50 mM sodium butyrate for 24 hours and 500 ng/ml TSA for 4 hours), NIH/3T3 (treated with 500 ng/ml TSA for 4 hours), C6 (treated with 500 ng/ml TSA for 4 hours), HeLa (treated with 500ng/ml TSA for 4 hours) |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:2500 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Histone H3 lysine 23 acetylation (H3K23ac) is a crucial epigenetic modification characterized by the addition of an acetyl group to the lysine residue at position 23 on the N-terminal tail of histone H3, a process catalyzed by specific histone acetyltransferases (such as p300/CBP) and reversible by deacetylases. Distinct from many other acetylation marks (e.g., H3K9ac, H3K27ac) that primarily enrich at active promoters or enhancers, H3K23ac exhibits a unique genomic distribution; it is widely present in euchromatin and notably enriched within gene bodies, particularly in exons. This specific localization suggests its function extends beyond transcriptional initiation to include roles in regulating transcription elongation, facilitating splice site recognition, and maintaining an open chromatin structure to prevent the erroneous spread of heterochromatin. Furthermore, H3K23ac plays a pivotal role in DNA damage response and specific developmental stages, while its dysregulation has been linked to various cancers and neurodevelopmental disorders, establishing it as an emerging and critical regulatory marker in contemporary epigenetic research.
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