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Description
CTGF Recombinant Rabbit mAb (S-3356)Product Specification Host Rabbit Antigen CTGF Synonyms CCN family member 2; Cellular communication network factor 2Imported; Connective tissue growth factor; Hypertrophic chondrocyte specific protein 24; Insulin like growth factor binding protein 8 (IBP 8; IGF binding protein 8; IGFBP 8); HCS24; IGFBP8; CCN2 Location Secreted Accession P29279 Clone Number S 3356 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HT
Product Specification
| Host | Rabbit |
| Antigen | CTGF |
| Synonyms | CCN family member 2; Cellular communication network factor 2Imported; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8 (IBP-8; IGF-binding protein 8; IGFBP-8); HCS24; IGFBP8; CCN2 |
| Location | Secreted |
| Accession | P29279 |
| Clone Number | S-3356 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HT-1080, HepG2, PANC-1 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
Background
Connective tissue growth factor (CTGF, also termed CCN2) is a 38 kDa, cysteine-rich, secreted matricellular protein of the CCN family that orchestrates cell adhesion, migration, proliferation, differentiation, angiogenesis, and extracellular matrix (ECM) remodeling by binding integrins, heparan sulfate proteoglycans, and growth factors such as TGF-β and VEGF through its four conserved domains (IGFBP, VWC, TSP-1, and cysteine-knot CT); physiologically it is indispensable for embryonic skeletal, pancreatic, ovarian, and vascular development, whereas dysregulated CTGF drives fibrosis, diabetic retinopathy, atherosclerosis, and tumorigenesis, making it a prominent therapeutic target now being pursued with monoclonal antibodies in pre-clinical and clinical trials.
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