Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 11 - Aug 16
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
eIF4E Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen eIF4E Synonyms Eukaryotic translation initiation factor 4E; eIF 4E; eIF4E; eIF 4F 25 kDa subunit; mRNA cap binding protein; EIF4EL1; EIF4F Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P06730 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, HeLa, MCF7, K562, NIH 3T3, mouse testis, PC 12, rat testis Predicted Reactivity
Product Specification
| Host | Rabbit |
| Antigen | eIF4E |
| Synonyms | Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; EIF4EL1; EIF4F |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P06730 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, HeLa, MCF7, K562, NIH/3T3, mouse testis, PC-12, rat testis |
| Predicted Reactivity | Bv, Rb, Xe |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
eIF4E（eukaryotic initiation factor 4E）is a crucial eukaryotic translation initiation factor. It plays a key role in the initiation of protein synthesis by recognizing and binding to the 7-methylguanosine cap structure at the 5' end of eukaryotic mRNA. This binding facilitates the recruitment of the ribosome and other initiation factors to the mRNA, thereby promoting the start of translation. eIF4E is highly conserved across different eukaryotic species and is involved in a variety of biological processes such as cell growth, proliferation, and differentiation. Its activity can be regulated by various mechanisms including phosphorylation and interaction with other proteins. Abnormal expression or function of eIF4E has been implicated in several diseases, including cancer, where it may contribute to tumor development and progression by promoting the translation of oncogenic mRNAs.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy