hnRNP U Recombinant Rabbit mAb (S-2375-23)

Heterogeneous nuclear ribonucleoprotein U (HNRNPU, also called scaffold attachment factor A/SAF-A) is a ~120 kDa, ubiquitously expressed nuclear protein that functions as a multifunctional hub integrating RNA metabolism, chromatin organization and transcriptional control: it binds both RNA and AT-rich scaffold/matrix attachment region DNA through N-terminal SAP and C-terminal RGG RNA-binding domains to organize 3-D chromatin architecture, regulate alternative pre-mRNA splicing by controlling U2 snRNP maturation and Cajal body morphology, stabilize or destabilize specific mRNAs via 3′-UTR interactions, and modulate RNA polymerase II elongation together with cofactors like p300/PCAF; its actions are essential for heart development (cardiac-specific deletion causes lethal dilated cardiomyopathy with widespread splicing defects), early neuronal differentiation and brain function (mutations produce intellectual disability, autism spectrum disorder and epilepsy), and it also participates in X-chromosome inactivation, telomere maintenance and protein homeostasis by acting as a pseudosubstrate for SCF ubiquitin ligases[^8].