SKU: 26041673975

VEGF-A Recombinant Rabbit mAb (S-3347)

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Description

VEGF-A Recombinant Rabbit mAb (S-3347)Product Specification Host Rabbit Antigen VEGF A Synonyms Vascular endothelial growth factor A, long form; L VEGF; Vascular permeability factor (VPF); VEGF; VEGFA Location Secreted Accession P15692 Clone Number S 3347 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample U 87 MG, HT 1080 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,

Product Specification


Host Rabbit
Antigen VEGF-A
Synonyms Vascular endothelial growth factor A, long form; L-VEGF; Vascular permeability factor (VPF); VEGF; VEGFA
Location Secreted
Accession P15692
Clone Number S-3347
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Positive Sample U-87 MG, HT-1080
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu

Background

Vascular Endothelial Growth Factor A (VEGF-A) is a 45 kDa homodimeric glycoprotein and the founding member of the VEGF family, encoded on chromosome 6p21.3 and expressed as at least seven splice isoforms (e.g., VEGF-A165) that are secreted or extracellular-matrix-bound to initiate angiogenesis and vascular permeability through binding VEGFR-2 on endothelial cells and neuropilin co-receptors, triggering PI3K-Akt, PLCγ-MAPK, and Src signaling cascades that drive endothelial proliferation, migration, and tube formation, while its transcription is up-regulated by hypoxia via HIF-1α and by growth factors such as PDGF and FGF, and its dysregulation underlies tumor neovascularization, diabetic retinopathy, and inflammatory disorders, making VEGF-A a pivotal therapeutic target for anti-angiogenic cancer drugs and anti-VEGF antibodies like bevacizumab.

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SKU: 26041673975

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4.1 ★★★★★
Based on 24 reviews
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Verified Purchase
Natures Retreat
Dallas, US
★★★★★ 3
Dog likes it
Flavor Name: Marshmallow & Peanut Butter, Size: Large
It wears faster on the longer side, my dog does love this, but 2 sides are not chewed as much.
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Reviewed in the United States on October 19, 2025
S
Verified Purchase
slz
Natrona Heights, US
★★★★★ 5
Terrific! Much easier to use than Kongs and my dog loves it.
Flavor Name: Peanut Butter, Size: Medium
I like these so much better than the original Kongs. The large opening makes it so much easier to put peanut butter or cream cheese into it. Plus much easier to clean out afterwards. My dog also likes to chew it and play with it throwing it in the air after he’s done eating the peanut butter. Very sturdy - he chews apart stuffed toys but his chewing hasn’t damaged this at all. I highly recommend this product!
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Reviewed in the United States on October 9, 2025
T
Verified Purchase
T Wolf
Los Angeles, US
★★★★★ 5
Great for strong chewing dogs. Entertaining too!
Flavor Name: Peanut Butter, Size: Medium
My black lab can destroy the toughest of dog chew toys, but he's not destroyed this peanut. I fill it with peanut butter, yogurt, pumpkin or apple sauce and freeze it. It keeps him entertained for quite a while. When the filling is gone, he leaves it alone or carries it around begging for a filled one.
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Reviewed in the United States on March 31, 2026
H
Verified Purchase
Heather Murphy
Grantham, US
★★★★★ 5
Super cute! If you have one dog it'll last a while. If you have more than one...buy two.
Flavor Name: Marshmallow & Peanut Butter, Size: Large
This is THE FAVORITE chew toy in our household. We have two grown labs and a 10 month old mutt and they all love this toy. They got a variety of chew toys at Christmas and this is the one that they steal from each other. That said, they've definitely managed to kill it. It's well worth the money and it's held up well to heavy chewers but four months later and we're going to have to buy a new one. It's now a stub. They managed to break off all the marshmallows about a week ago and the stick itself is more like a chunk now but we definitely got our money's worth.
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Reviewed in the United States on May 1, 2025
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Verified Purchase
AvidShopper333
Phoenix, US
★★★★★ 5
Lasting 6 months in! Great smell.
Flavor Name: Marshmallow & Peanut Butter, Size: Large
This actually does smell like marshmallows which is definitely more pleasant than most dog chews!! It has held up to our power chewer. It’s a bit heavy for our smaller dog but he manages and it’s quite funny!! It’s a bit hard but that’s why it is holding up. Would buy again if this one ever wears out.
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Reviewed in the United States on January 3, 2026

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