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Description
ATM Recombinant Rabbit mAb (S-2178-4)Product Specification Host Rabbit Antigen ATM Synonyms Serine protein kinase ATM; Ataxia telangiectasia mutated (A T mutated) Immunogen Recombinant Protein Location Nucleus Accession Q13315 Clone Number S 2178 4 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, HepG2, HeLa, Raji, MCF7, A549, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | ATM |
| Synonyms | Serine-protein kinase ATM; Ataxia telangiectasia mutated (A-T mutated) |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | Q13315 |
| Clone Number | S-2178-4 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, HepG2, HeLa, Raji, MCF7, A549, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:50-1:100 | Hu, Ms |
Background
The ATM protein, which stands for Ataxia Telangiectasia Mutated protein, is a crucial enzyme involved in the cellular response to DNA damage. It is a serine/threonine kinase that plays a central role in initiating the DNA damage response pathway when double-strand breaks occur in the DNA. Upon activation by DNA damage signals, ATM phosphorylates a wide range of downstream targets, including key proteins like p53, BRCA1, and the MRE11-RAD50-NBS1 complex. These phosphorylation events help to trigger cell cycle arrest, allowing the cell to repair the damaged DNA, and also promote apoptosis if the damage is too severe to be repaired. Mutations in the gene encoding ATM are associated with the rare genetic disorder Ataxia Telangiectasia, which is characterized by neurological defects, immunodeficiency, and an increased risk of cancer, highlighting the essential role of ATM in maintaining genomic stability and preventing tumorigenesis.
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