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Description
Transthyretin/Prealbumin His Tag Protein, HumanProduct Specification Species Human Synonyms TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651,Transthyretin Accession P02766 Amino Acid Sequence Gly21 Glu147 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 15 20kDa&30 40kDa(Reducing) Purity 95% by SDS PAGE & > 95% SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg
Product Specification
| Species | Human |
| Synonyms | TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651,Transthyretin |
| Accession | P02766 |
| Amino Acid Sequence | Gly21-Glu147 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 15-20kDa&30-40kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE & > 95% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Alexander KM, Davis MK, Akinboboye O, Berk J, Bhatt K, Cappelli F, Cuddy SAM, Fontana M, Garcia-Pavia P, Gillmore JD, Griffin JM, Grodin JL, Judge DP, Khouri MG, Lam K, Masri A, Maurer MS, Obici L, Ruberg FL, Sarswat N, Shah K, Soman P, Stern L, Wright R, Xiong K, Cao X, Lystig T, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Solomon SD, Grogan M. Efficacy of Acoramidis in Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM and Its Open-Label Extension. JAMA Cardiol. 2025 Nov 8:e254477. |
Background
Transthyretin (TTR) is a tetramer composed of four identical subunits, with each monomer rich in β-sheets and forming an internal channel within its structure for ligand binding. It primarily functions as a transport carrier in the blood and cerebrospinal fluid, responsible for transporting thyroid hormone thyroxine (T4) and retinol (vitamin A). Genetic mutations or age-related misfolding of TTR can lead to its aggregation into amyloid fibrils, triggering a series of diseases known as transthyretin amyloidosis (ATTR), including both hereditary and wild-type amyloidosis, which can affect multiple organs such as nerves, heart, and eyes. Consequently, this protein is a key target for disease diagnosis, disease monitoring, and emerging therapies (such as stabilizing the tetrameric structure or clearing amyloid deposits).
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