SKU: 34742400862

Osteoprotegerin/TNFRSF11B His Tag Protein, Human

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Description

Osteoprotegerin/TNFRSF11B His Tag Protein, HumanProduct Specification Species Human Synonyms OCIF,OPG Accession O00300 Amino Acid Sequence Glu22 Leu401 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 50 60kDa (Reducing) Purity 95% by SDS PAGE Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.

Product Specification


Species Human
Synonyms OCIF,OPG
Accession O00300
Amino Acid Sequence

Glu22-Leu401 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight

50-60kDa (Reducing)

Purity >95% by SDS-PAGE
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Reference

Shin SY, Kang IS, Kim C. ERK inhibits osteoclast differentiation in RAW 264.7 cells through the osteoprotegerin-mediated autophagy. Bone. 2025 Apr;193:117424.
2.Radhi JH, El-Hagrasy AMA, Almosawi SH, Alhashel A, Butler AE. The Role of Osteoprotegerin in Breast Cancer: Genetic Variations, Tumorigenic Pathways, and Therapeutic Potential. Cancers (Basel). 2025 Jan 21;17(3):337.

Background

Osteoprotegerin (OPG/TNFRSF11B/OCIF) is a member of the tumor necrosis factor receptor superfamily, secreted by osteoblasts as a homodimeric protein.Its core function is as a decoy receptor: 1) By binding with high affinity to RANKL, it competitively blocks RANKL from activating its functional receptor RANK, thereby strongly inhibiting osteoclast differentiation and activation while promoting their apoptosis, making it a key negative regulator of bone resorption. 2) It can also bind to TRAIL (TNFSF10), exerting an anti-apoptotic effect.Bone homeostasis directly depends on the local RANKL/OPG concentration ratio.As a central molecule in maintaining bone metabolic balance, abnormalities in its mechanism are closely associated with osteoporosis. Furthermore, studies suggest it plays important roles in regulating lymph node development and preventing vascular calcification, while its interaction with TRAIL may have implications in oncology and other fields.

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SKU: 34742400862

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Cuba, US
★★★★★ 5
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Color: Brown, Size: 13"D x 17"W x 33"H, Color: Brown, Size: 13"D x 17"W x 33"H
Great piece for my den. Classic look and fits my preppy style well. Easy to assemble.
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Reviewed in the United States on February 24, 2026
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★★★★★ 5
Great Bar Cart/Coffee Bar
Color: Brown, Size: 13"D x 23.7"W x 32.7"H
Easy set up, good size, great for decor and holding bottles!
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Reviewed in the United States on January 3, 2026
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SubParChaosCoordinator
Cuba, US
★★★★★ 5
Perfect for the Price!
Color: Greige, Size: 13"D x 23.7"W x 32.7"H
The bar cart was very easy to put together. I can be "mechanically challenged" and was able to do it myself LOL It's nice and sturdy, the wheels roll smooth when you move it. The size is perfect for the small wall I have it against. I have several bottles of liquor and bartending mixer set on top, and about 20 various glassware on the 2nd shelf. The bottom shelf is taller, and does let you stand larger bottles down there. The one racks will only for the smaller size, but does hold them well.
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Reviewed in the United States on November 6, 2024
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Christian
Houston, US
★★★★★ 3
Decent bar cart, but very annoying assembly
Color: Marble White, Size: 13"D x 23.7"W x 32.7"H
I think it looks nice and is decent value, but this thing is a pain to put together. Instead of just sending 3 shelves, you get 6 pieces to connect together to make 3 shelves. On top of that - they don’t even really connect. It would be 1000x easier if they added a couple of wooden pegs to connect the 2 pieces together. Instead, you have to do a balancing act which is tedious as can be. I ended up super glueing 2 of the 3 shelves togethers after how annoying the first was, so I would highly recommend you do the same. The whole process of putting it together feels like a balancing act. For something so small, it’s about as annoying as possible to put together. Nearly every step requires you to balance something and screw it in. Most of this would be alleviated if, as I said, it was just 3 pieces for the shelves instead of 6. But, you get what you pay for. Overall, I can’t complain too much for the price and result, but I wasn’t a fan of building it. It’d also look a little nicer if each shelf didn’t have a crack going through it.
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Reviewed in the United States on March 14, 2026
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T. P.
Chelsea, US
★★★★★ 5
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Color: Black, Color: Black
This sink caddy is very pretty. It is easy to use. It has slots for brushes and whatnot. Keep in mind that not all soap bottles will fit in it though. I had to adjust my soap bottle to fit, so it kind of took up space where I could have put a little more things that same space. If you have round sponges like the ones I have, they can fit where you put the soap dispenser. It just all depends on what size soap dispenser you have in there. The quality has been good so far. It's easy to clean the bottom of the tray. It simply just slides in and out. Very easy. I recommend this.
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Reviewed in the United States on November 20, 2025

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