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Description
Biotin Rat Anti-Mouse CD184 Antibody (S-R670)Product Specification Host Rat Antigen CD184 Synonyms C X C chemokine receptor type 4; CXC R4; CXCR 4; Fusin; Leukocyte derived seven transmembrane domain receptor (LESTR); Pre B cell derived chemokine receptor (PB CKR); Stromal cell derived factor 1 receptor (SDF 1 receptor); Cmkar4; Lestr; Sdf1r; Cxcr4 Location Cell membrane Accession P70658 Clone Number S R670 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL
Product Specification
| Host | Rat |
| Antigen | CD184 |
| Synonyms | C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; Leukocyte-derived seven transmembrane domain receptor (LESTR); Pre-B-cell-derived chemokine receptor (PB-CKR); Stromal cell-derived factor 1 receptor (SDF-1 receptor); Cmkar4; Lestr; Sdf1r; Cxcr4 |
| Location | Cell membrane |
| Accession | P70658 |
| Clone Number | S-R670 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
CD184, also known as CXCR4, is a seven-transmembrane G-protein-coupled chemokine receptor that—after binding its unique ligand CXCL12 (SDF-1)—triggers multiple signaling cascades (PI3K/AKT, JAK/STAT, ERK1/2, Hedgehog) governing immune cell trafficking, plasma-cell homing to bone-marrow niches, embryonic development, hematopoiesis, angiogenesis, and cancer stem-cell maintenance, while its overexpression or mutations underlie WHIM syndrome, HIV entry, tumor progression and metastasis, making it a key therapeutic target in oncology and immunology.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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