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Description
NFKB1 Protein,HumanProduct Specification Species Human Synonyms DNA binding factor KBF1; EBP 1; Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 Accession P19838 2 Amino Acid Sequence Met1 Gly434 Expression System E. coli Molecular Weight 49. 7 KDa Purity 90% by SDS PAGE Endotoxin <1EU g Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris HCl, 150mM NaCl, 20mM GSH, pH 8. 0. Reconstitution Always centrifuge tubes before
Product Specification
| Species | Human |
| Synonyms | DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Accession | P19838-2 |
| Amino Acid Sequence | Met1-Gly434 |
| Expression System | E.coli |
| Molecular Weight | 49.7 KDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris-HCl, 150mM NaCl, 20mM GSH, pH 8.0. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Stability & Storage |
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Background
The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
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