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Description
Calbindin Recombinant Rabbit mAb(SDT-034-11)Product Specification Host Rabbit Antigen Calbindin Synonyms Calbindin D 28K,CALB1,CAB27, Vitamin D dependent calcium binding protein Immunogen Synthetic Peptide Accession P05937 Clone Number SDT 034 11 Antibody Type Rabbit mAb Application WB, IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Or, Bv Purification Protein A Concentration 0. 5mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | Calbindin |
| Synonyms | Calbindin D-28K,CALB1,CAB27, Vitamin D-dependent calcium-binding protein |
| Immunogen | Synthetic Peptide |
| Accession | P05937 |
| Clone Number | SDT-034-11 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or, Bv |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:4000-8000 | |
| WB | 1:1000 |
Background
Calbindin contains 4 active calcium-binding domains, and 2 modified domains that have lost their calcium-binding capacity. Calbindin acts as a calcium buffer and calcium sensor and can hold four Ca2+ in the EF-hands of loops EF1, EF3, EF4 and EF5. Calbindin is a vitamin D–responsive gene in many tissues, in particular the chick intestine, where it has a clear function in mediating calcium absorption. In the brain, its synthesis is independent of vitamin-D. Although it was originally proposed that the major role of calbindin is to facilitate the vitamin D dependent movement of calcium through the cytosolic compartment of the intestinal or renal cell, it was found that calbindin also has a major role in different cell types in protecting against apoptotic cell death.
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