CD117/c-Kit Fc Chimera Protein, Mouse
SKU: 47219130516

CD117/c-Kit Fc Chimera Protein, Mouse

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Description

CD117/c-Kit Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD117 antigen; CD117; ckit; c kit; EC 2. 7. 10; EC 2. 7. 10. 1; KIT; PBT; piebald trait; Proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCF R; SCFR; SCFRmast stem cell growth factor receptor; soluble KIT variant 1; Tyrosine protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Accession P05532

Product Specification


Species Mouse
Synonyms CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Accession P05532-2
Amino Acid Sequence Ser25-Pro523, with C-terminal His
Expression System HEK293
Molecular Weight 95-120kDa (Reducing)
Purity >95% by SDS-PAGE & >95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference


1.Kimura, Y. et al. (2011) PLoS ONE 6:e26918. 2.Tallini, Y.N. et al. (2009) Proc. Natl. Acad. Sci. USA 106:1808. 3.Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 4.Sun, L. et al. (2004) J. Clin. Invest. 113:1364.

Background

Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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SKU: 47219130516

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Amy
Boise, US
★★★★★ 5
These work!
Size: M (up to size 9)-Beige
I’ve had dry cracked feet my whole life. Tried these last night with lotion from Trader Joe’s and literally overnight my feet are the softest they’ve ever been. I put a pair of socks over them and went to sleep with them on. Hard to walk around with all that slippery-ness but worth it! 10/10✨👌
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Reviewed in the United States on June 11, 2025
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View from the hills
Whiting, US
★★★★★ 5
Enables the person to move around while wearing.
These silicon socks look a bit odd at first glance but they work great and best of all, any lotions and oily creams are contained on the inside so you can walk around. They are very soft. I haven't had them long so I can't comment on durability, but they are not made of lightweight material.
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Reviewed in the United States on March 10, 2026
T
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Theresa C.
New York, US
★★★★★ 5
They Work
Husband struggles with cracking feet, he has tried so many home remedies these work great to keep the moisturizer on and the carpet dry!
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Reviewed in the United States on March 25, 2026
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Verified Purchase
raymond jones
Charlottesville, US
★★★★★ 1
Not worth the time or money
Never buy these, they causes feet cramps and bad pain even if you use foot pain cream
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Reviewed in the United States on April 30, 2026
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Greg from MidW
Lowell, US
★★★★★ 3
Does the job but dangerous to walk with!
Does the job but dangerous to walk with: foot is sliding inside the sock if the foot was treated with cream or lotion prior. It is uncomfortable to sleep with but a necessary hurdle to heal your heels!
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Reviewed in the United States on December 24, 2025

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