SKU: 48813744276

Alexa Fluor® 647 Mouse Anti-Human MICA Antibody (S-2794)

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Description

Alexa Fluor® 647 Mouse Anti-Human MICA Antibody (S-2794)Product Specification Host Mouse Antigen MICA Synonyms MHC class I polypeptide related sequence A; MIC A; PERB11. 1 Location Cytoplasm, Cell membrane, Endoplasmic reticulum Accession Q29983 Clone Number S 2794 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample HeLa Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3%

Product Specification


Host Mouse
Antigen MICA
Synonyms MHC class I polypeptide-related sequence A; MIC-A; PERB11.1
Location Cytoplasm, Cell membrane, Endoplasmic reticulum
Accession Q29983
Clone Number S-2794
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample HeLa
Purification Protein G
Concentration 0.05mg/ml
Conjugation Alexa Fluor® 647
Physical Appearance Liquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

MICA (MHC class I polypeptide-related sequence A) is a critical immune regulatory protein belonging to the non-classical MHC class I family. Encoded by the MICA gene on human chromosome 6, it is typically expressed on epithelial cells, fibroblasts, and endothelial cells, with upregulated expression under stress conditions such as infection, heat shock, or malignant transformation. Structurally, MICA resembles classical MHC class I molecules, featuring α1, α2, and α3 extracellular domains, but unlike MHC I, it does not bind β2-microglobulin or present antigens. Its primary function involves interaction with the activating receptor NKG2D (Natural Killer Group 2 Member D) on NK cells and cytotoxic T cells, triggering cytotoxicity and cytokine production, thereby playing a key role in antitumor and antimicrobial immunity. Tumors often evade immune surveillance by proteolytic shedding of MICA, making it a significant target in cancer immunotherapy. MICA's high polymorphism (over 100 alleles) is also associated with autoimmune diseases and transplant rejection. Additionally, certain viruses (e.g., cytomegalovirus) encode proteins that disrupt MICA-NKG2D interactions to evade immune clearance.

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SKU: 48813744276

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Dayana Llamos Castro
Pawtucket, US
★★★★★ 5
Perfect Sunscreen for Acne-Prone Skin! ☀️✨
Size: 2.5 Fl Oz (Pack of 1)
I absolutely love this sunscreen! Eucerin has honestly become one of my favorite skincare brands because this is one of the only sunscreens that works well with my acne-prone skin. It doesn’t feel heavy or greasy, doesn’t clog my pores, and most importantly, it doesn’t break me out. The finish feels lightweight and comfortable for everyday wear. The only small downside is that if it gets into your eyes, it can burn a little, so I try to avoid applying it too close to the eye area. Other than that, it’s amazing and I will definitely keep repurchasing it
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Reviewed in the United States on May 21, 2026
M
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Merilyn dicent
Bozeman, US
★★★★★ 5
Really good spf
Size: 2.5 Fl Oz (Pack of 1)
I’ve been using this for a little while now and I actually really like it. It feels nice on the skin, doesn’t feel heavy, and leaves my face looking fresh and smooth. I also noticed my skin feels softer after using it consistently. Definitely something I would buy again.
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Reviewed in the United States on May 17, 2026
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Sam
Birmingham, US
★★★★★ 5
Pretty lightweight
Size: 2.5 Fl Oz (Pack of 1)
Although it still leaves a little bit of a shine ( more of a dewy look), there is definitely not that much of a greasy feel which really helps me to keep being consistent with using sunscreen because my big issue with using other sunscreens is that they're too greasy feeling and not lightweight and leave too much of a shine on my already oily face.
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Reviewed in the United States on May 1, 2026
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Mayte Peña
Dallas, US
★★★★★ 5
Fluid
Size: 2.5 Fl Oz (Pack of 1)
I love the texture it has, it's very good and fluid The container is big
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Reviewed in the United States on May 17, 2026
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brisia
San Leandro, US
★★★★★ 4
Not for sensitive skin
Size: 2.5 Fl Oz (Pack of 1)
I have combination skin, prone to acne, and sensitive skin. Even though this is labeled as non-comedogenic and best suited for oily skin, I still experienced acne because the consistency of the sunscreen is really thick. It makes it hard to blend (really hard) and upsets my skin. It also smells a lot like alcohol, more so than most sunscreens, even those from this brand. I bet it's good for some skins but it simply wasn't for me.
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Reviewed in the United States on May 7, 2026

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