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Description
CA4 Recombinant Rabbit mAb (S-2339-24)Product Specification Host Rabbit Antigen CA4 Synonyms Carbonic anhydrase 4; Carbonate dehydratase IV; Carbonic anhydrase IV (CA IV) Immunogen Synthetic Peptide Location Cell membrane Accession P22748 Clone Number S 2339 24 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | CA4 |
| Synonyms | Carbonic anhydrase 4; Carbonate dehydratase IV; Carbonic anhydrase IV (CA-IV) |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P22748 |
| Clone Number | S-2339-24 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
Carbonic anhydrase IV (CA4) is a glycosylphosphatidylinositol-anchored membrane-bound zinc metalloenzyme that catalyzes the reversible hydration of CO₂ to bicarbonate and protons, playing a pivotal role in CO₂ and pH homeostasis across ocular, renal, pulmonary, and cerebrovascular endothelia; expressed abundantly on the luminal surface of capillaries and in the renal proximal tubule brush border, CA4 facilitates rapid CO₂ elimination, modulates cerebrovascular reactivity, and supports retinal photoreceptor function, with mutations linked to retinitis pigmentosa 17 and its pharmacological inhibition explored for glaucoma, altitude sickness, and edema therapy.
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