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Description
Phospho-YAP (Ser127) Recombinant Rabbit mAb (S-4250)Product Specification Host Rabbit Antigen Phospho YAP (Ser127) Synonyms Transcriptional coactivator YAP1; Yes associated protein 1; Protein yorkie homolog; Yes associated protein YAP65 homolog; YAP65; YAP1 Location Cytoplasm, Nucleus, Cell membrane Accession P46937 Clone Number S 4250 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample A431, PANC 1, Calyculin A treated HeLa, NIH 3T3, C2C12, C6
Product Specification
| Host | Rabbit |
| Antigen | Phospho-YAP (Ser127) |
| Synonyms | Transcriptional coactivator YAP1; Yes-associated protein 1; Protein yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; YAP1 |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | P46937 |
| Clone Number | S-4250 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A431, PANC-1, Calyculin A treated HeLa, NIH/3T3, C2C12, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
Background
Phospho-YAP (Ser127) is a phosphorylated form of the Yes-associated protein (YAP), which is a key transcriptional coactivator in the Hippo signaling pathway. YAP regulates various cellular processes, including cell proliferation, survival, differentiation, and organ size. The phosphorylation of YAP at serine 127 by kinases such as MST1/2 and LATS1/2 leads to its inactivation and cytoplasmic retention. When dephosphorylated, YAP can translocate to the nucleus and promote gene transcription. For example, androgen exposure can suppress the inhibitory phospho-Ser127 modification on YAP, resulting in increased YAP nuclear abundance and activity. This regulation is crucial for understanding the role of YAP in diseases like cancer.
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