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Description
Biotinylated PD-1 Fc&Avi Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms PD 1; Programmed cell death protein 1; CD279; hPD 1; PDCD1; HPD L; HSLE1; SLEB2 Accession B0LAJ3 Amino Acid Sequence Leu25 Gln167, with C terminal hIgG1 Fc+Avi tag Expression System HEK293 Molecular Weight 55 72kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Biotin Tag Human Fc Tag, Avi Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute
Product Specification
| Species | Cynomolgus |
| Synonyms | PD-1; Programmed cell death protein 1; CD279; hPD-1; PDCD1; HPD-L; HSLE1; SLEB2 |
| Accession | B0LAJ3 |
| Amino Acid Sequence | Leu25-Gln167, with C-terminal hIgG1 Fc+Avi tag |
| Expression System | HEK293 |
| Molecular Weight | 55-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Human Fc Tag, Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Nishimura, H et al. (1996) Int. Immunol. 8:773. 2. Keir, M.E. et al. (2008) Annu. Rev. Immunol. 26:677. 3. Butte, M.J. et al. (2007) Immunity 27:111. |
Background
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. Mature Cynomolgus monkey PD-1 consists of a 148 amino acid (aa) extracellular region (ECD) with one immunoglobulin-like V-type domain, a 24 aa transmembrane domain, and a 95 aa cytoplasmic region. The Cynomolgus monkey PD-1 ECD shares 95% aa sequence identity with the human PD-1 ECD. The cytoplasmic tail contains two tyrosine residues that form the immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important for mediating PD-1 signaling. PD‑1 is expressed on activated T cells, B cells, monocytes, and dendritic cells while. PD-L1 expression is constitutive on the same cells and also on nonhematopoietic cells such as lung endothelial cells and hepatocytes. Ligation of PD-L1 with PD-1 induces co-inhibitory signals on T cells promoting their apoptosis, anergy, and functional exhaustion.
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