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Description
Fc epsilon RI α His Tag Protein, HumanProduct Specification Species Human Synonyms FCE1AFcERI Accession P12319 1 Amino Acid Sequence Val26 Gln205, with C terminal His Expression System HEK293 Molecular Weight 43 55 kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 2 Reconstitution Reconstitute at less than 1 mg mL according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | FCE1A；FcERI |
| Accession | P12319-1 |
| Amino Acid Sequence | Val26-Gln205, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 43-55 kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.2 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Fc epsilon RI α, also known as FCER1A, is the α subunit of immunoglobulin receptor (IgE receptor). IgE receptor consists of one α subunit, one β subunit and two γ subunits. The α subunit includes extracellular domain and transmembrane domain, and the extracellular region contains two immunoglobulin-like domains, in which the proximal membrane end is the binding region to IgE Fc, and the other end is related to high affinity. The α subunit contains seven N-chain glycosylation sites, which can guide the correct folding of the α-chain. β subunit is divided into transmembrane region and intracellular region, which is a four-time transmembrane molecule with immune receptor tyrosine activation motif (ITAM). The γ subunits are connected by disulfide bonds and each has a transmembrane region. Fc epsilon RI α first initiates anaphylaxis. Allergens act on mast cells through IgE and Fc epsilon RI α, activate chemical mast cells through signal transduction, release vasoactive mediators such as histamine and bradykinin to cause hypersensitivity, or pre-release Leucotrienes, leukotrienes and platelet activating factors to cause inflammation.
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