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Description
SOD2/MnSOD (acetyl K68) Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen SOD2 MnSOD (acetyl K68) Synonyms Superoxide dismutase [Mn], mitochondrial Immunogen Synthetic Peptide Location Mitochondrion Accession P04179 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | SOD2/MnSOD (acetyl K68) |
| Synonyms | Superoxide dismutase [Mn], mitochondrial |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P04179 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Hu |
Background
SOD2 (acetyl K68) refers to the acetylation of lysine 68 (K68) on superoxide dismutase 2 (SOD2), a mitochondrial antioxidant enzyme critical for neutralizing superoxide radicals and protecting cells from oxidative stress. This post-translational modification, mediated by acetyltransferases such as SIRT3 (which can also deacetylate it), enhances SOD2 activity, improving its ability to scavenge reactive oxygen species (ROS) and maintain mitochondrial function. Acetylation at K68 influences SOD2’s structural stability and enzymatic efficiency, playing a key role in aging, metabolic regulation, and diseases like cancer, neurodegeneration, and cardiovascular disorders. Dysregulation of SOD2 (acetyl K68) is linked to increased oxidative damage, making it a potential therapeutic target for conditions involving mitochondrial dysfunction and oxidative stress.
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