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Description
Biotin Mouse Anti-Human/Mouse TCF-7/TCF-1 Antibody (S-4484)Product Specification Host Mouse Antigen TCF1 TCF7 Synonyms Transcription factor 7; T cell specific transcription factor 1 (T cell factor 1; TCF 1); TCF1; TCF7 Location Nucleus Accession P36402Q00417 Clone Number S 4484 Antibody Type Mouse mAb Isotype IgG1,k Application ICFCM Reactivity Hu, Ms Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03%
Product Specification
| Host | Mouse |
| Antigen | TCF1/TCF7 |
| Synonyms | Transcription factor 7; T-cell-specific transcription factor 1 (T-cell factor 1; TCF-1); TCF1; TCF7 |
| Location | Nucleus |
| Accession | P36402、Q00417 |
| Clone Number | S-4484 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu, Ms |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Hu |
Background
TCF1 (T-cell factor 1), encoded by the TCF7 gene, is a 48–58 kDa sequence-specific HMG-box transcription factor and a founding member of the TCF/LEF family that serves as the primary nuclear effector of the canonical Wnt/β-catenin pathway, binding via its N-terminal β-catenin interaction domain and its central DNA-binding HMG motif to the consensus sequence 5’-(A/T)(A/T)CAAAG-3’ in promoters/enhancers of genes such as MYC, CCND1 and LEF1, thereby driving embryonic stem cell pluripotency, thymic T-cell lineage specification, CD8⁺ T-cell memory formation, and adult intestinal epithelial renewal, while its expression is dynamically regulated by alternative promoters and differential splicing to yield long (p45) and short (p33) isoforms with opposing activities; TCF1 also possesses context-dependent repressive functions when β-catenin is absent, interacts with Groucho/TLE co-repressors, and is frequently inactivated by loss-of-function mutations or deletions in colorectal, hematopoietic and other malignancies, making it both a developmental gatekeeper and a tumor suppressor.
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