SKU: 64897659155

Mouse Anti-Human TCR α/β Antibody (S-R686)

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Description

Mouse Anti-Human TCR α/β Antibody (S-R686)Product Specification Host Mouse Antigen TCR Synonyms TCR; TCR Location Cell membrane Accession P01848 P01850 Clone Number S R686 Antibody Type Mouse mAb Application FCM Reactivity Hu Positive Sample Human PBMC Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Dilution application dilution species FCM 1: 200 Hu

Product Specification


Host Mouse
Antigen TCR α/β
Synonyms α/β TCR; TCR α/β
Location Cell membrane
Accession P01848、 P01850
Clone Number S-R686
Antibody Type Mouse mAb
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 1:200 Hu

Background

The T cell receptor (TCR) α and β proteins are essential components of the αβ T cell receptor, a heterodimeric surface protein expressed on T lymphocytes that recognizes antigenic peptides presented by major histocompatibility complex (MHC) molecules. The TCR α chain is encoded by the TRAC (T cell receptor alpha constant) and TRAV (T cell receptor alpha variable) genes, while the TCR β chain is encoded by the TRBC (T cell receptor beta constant) and TRBV (T cell receptor beta variable) genes, along with diversity (TRBD) and joining (TRBJ) segments, enabling extensive combinatorial diversity. Structurally, both chains consist of a variable (V) domain responsible for antigen recognition and a constant (C) domain that anchors the receptor to the cell membrane. The TCR αβ heterodimer associates with the CD3 complex (CD3γε, CD3δε, and CD247 ζζ) to form a functional TCR-CD3 signaling unit, which transmits activation signals upon peptide-MHC engagement. TCR β undergoes V(D)J recombination during thymic development, contributing to the receptor's antigen specificity, whereas TCR α lacks a D segment but still undergoes recombination for diversity. Mutations or dysregulation in TCR α/β genes can lead to immune disorders, including T cell malignancies and autoimmune diseases. TCR αβ T cells are critical for adaptive immunity, mediating responses against infections, tumors, and self-antigens in autoimmune conditions.

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SKU: 64897659155

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Jim Pierce
Waukegan, US
★★★★★ 5
Awesome.
Material Type: Recycled Polyester, Color: Light Grey Heather, Size: X-Large
Fleece jacket is nothing short of awesome. I picked up a few over the years and always been pleased with them. Worn to work, for casual wear, And now that i'm retired just around the house to keep warm. They wear well, Wash well, Hold their shape stitching and zippers. Watching their price I scored this win for twelve dollars and sixty cents. They lend themselves well to layering as well. A real value in this day and age. Very true to size very comfortable.
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Reviewed in the United States on February 5, 2026
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Reviewer123
New York, US
★★★★★ 5
So Soft and Warm
Material Type: Recycled Polyester, Color: Black, Size: Small
Great quality fleece for the price. It’s soft, warm, and fits true to size without feeling bulky. The quarter-zip design makes it easy to layer, and it looks nice enough for everyday wear. I’d definitely buy this again.
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Reviewed in the United States on January 21, 2026
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Amazon Customer
Draper, US
★★★★★ 5
Good Value!
Material Type: Recycled Polyester, Color: Blue Heather, Size: XX-Large
I bought one of these jackets a few years ago it is fairly thick and is great for outdoor wear. This new one is thinner material by quite a bit, but still well made. I like the zippered pockets. It is fuzzy and comfortable. Might even buy a third one in a different color!
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Reviewed in the United States on January 23, 2026
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George W. Shorago
Pawtucket, US
★★★★★ 3
Sizing too small
Material Type: Recycled Polyester, Color: Oatmeal Heather, Size: Medium
Warm and comfortable. BUT, the sizing is off. I ordered a medium , but it fit like a small:definitely order one size larger than you usually wear.
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Reviewed in the United States on April 15, 2026
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BPGLEFT
Bozeman, US
★★★★★ 5
Quality with a perfect fit!
Material Type: Recycled Polyester, Color: Forest Green, Size: X-Large
This has a nice weight to it and fits my husband perfectly and the length on the arms are prefect. I bought my husband a Lands End fleece and found that I liked this a lot better! The Land's End fleece was nice, but the sleeves are way too long! This was a much better price and will be back for more! Also has a great color assortment.
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Reviewed in the United States on December 2, 2025

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