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Description
IL-11 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms Interleukin 11, IL11 Accession P20808 Amino Acid Sequence Pro 22 Leu 199 with His Tag at the N Terminus Expression System HEK293 Molecular Weight 20 26kDa (Reducing) Purity 95% by SDS PAGE,> 90% by HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Cynomolgus |
| Synonyms | Interleukin-11, IL11 |
| Accession | P20808 |
| Amino Acid Sequence | Pro 22 - Leu 199 with His Tag at the N-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 20-26kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE,> 90% by HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Li X, Pang PS, Zhang S, Ru L, Yuan Z, Liu R, Choo QL, Wang Q, Song J, Xu Q, Zhang K, Yu KM, Xu Z. Immunogenicity and toxicokinetics assessment of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys. Life Sci. 2020 Oct 15;259:118244. |
Background
IL-11 (Interleukin-11) is a 178-amino-acid four-helix bundle cytokine belonging to the IL-6 family, which activates the JAK/STAT3 signaling pathway by binding to the specific IL-11 receptor alpha chain (IL-11Rα) and recruiting the gp130 co-receptor to form a heterodimeric complex. Structurally, IL-11 consists of four antiparallel α-helices (A-D) that constitute the typical cytokine fold, with helices A and C, as well as B and D, forming two pairs of parallel arrangements connected by two long loop regions—this structural feature determines its high-affinity binding to the receptor. Functionally, IL-11 exhibits pleiotropic biological activities: as a hematopoietic growth factor, it stimulates megakaryocyte maturation and thrombopoiesis; in mucosal protection, it promotes intestinal epithelial cell proliferation and repair; it also possesses anti-inflammatory properties by suppressing pro-inflammatory cytokine production from macrophages; additionally, it participates in bone metabolism regulation, neuroprotection, and reproductive processes. Clinically, recombinant human IL-11 (Oprelvekin) was the first approved therapeutic agent for chemotherapy-induced thrombocytopenia, significantly reducing bleeding risks and transfusion requirements in cancer patients; recent studies have revealed that IL-11 is overexpressed in pulmonary fibrosis, rheumatoid arthritis, and various malignancies (such as gastric and colorectal cancers), where it promotes tissue fibrosis and tumor invasion and metastasis, thereby establishing IL-11 signaling inhibition as a potential new therapeutic target for fibrotic diseases and cancer, with relevant antibody drugs currently under clinical development.
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