Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 16 - Aug 21
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Phospho-PERK (Thr980) Recombinant Rabbit mAb (S-1801-106)Product Specification Host Rabbit Antigen Phospho PERK (Thr980) Synonyms Eukaryotic translation initiation factor 2 alpha kinase 3; PRKR like endoplasmic reticulum kinase; Pancreatic eIF2 alpha kinase; Protein tyrosine kinase EIF2AK3; Pek; Perk; Eif2ak3 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q9Z2B5 Clone Number S 1801 106 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HeLa treated
Product Specification
| Host | Rabbit |
| Antigen | Phospho-PERK (Thr980) |
| Synonyms | Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Protein tyrosine kinase EIF2AK3; Pek; Perk; Eif2ak3 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q9Z2B5 |
| Clone Number | S-1801-106 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HeLa treated with 1 µM thapsigargin |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
Background
Phospho-PERK (Thr980) is a phosphorylated form of the protein kinase-like endoplasmic reticulum kinase (PERK), a type I transmembrane protein located in the endoplasmic reticulum (ER). It plays a crucial role in the unfolded protein response (UPR) by activating itself through oligomerization and autophosphorylation at threonine 980 (Thr980) in response to ER stress and the accumulation of misfolded proteins. This phosphorylation enhances PERK's activity, allowing it to phosphorylate eukaryotic translation initiation factor 2 alpha (eIF2α), which leads to the attenuation of translation initiation and global protein synthesis. This process helps protect cells from the toxic effects of misfolded proteins and maintains cellular homeostasis. Additionally, the activation of PERK is associated with cell cycle arrest due to the loss of cyclin D1 and the regulation of genes involved in metabolism, redox status, and apoptosis.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy