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Description
FGF-1 Protein, MouseProduct Specification Species Mouse Synonyms FGF 1, Acidic fibroblast growth factor(aFGF), Heparin binding growth factor 1(HBGF 1) Accession P61148 Amino Acid Sequence Phe16 Asp155 Expression System E. coli Molecular Weight 17 18kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM PB, 150mM NaCl, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Mouse |
| Synonyms | FGF-1, Acidic fibroblast growth factor(aFGF), Heparin-binding growth factor 1(HBGF-1) |
| Accession | P61148 |
| Amino Acid Sequence | Phe16-Asp155 |
| Expression System | E.coli |
| Molecular Weight | 17-18kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM PB, 150mM NaCl, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Zakrzewska M. et al. (2008) FGF-1: from biology through engineering to potential medical applications. Crit Rev Clin Lab Sci. 45(1): 91-135. 2、Pye D A. et al. (2000) Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: differential requirements for the modulation of FGF-1 and FGF-2. Glycobiology. 10(11): 1183-1192. |
Background
Fibroblast growth factor 1 (FGF-1), known as acidic fibroblast growth factor (FGF-Acidic), is one of the best characterized members of the FGF superfamily. FGF-1 is a powerful mitogen exhibiting strong action on numerous different cell types. It plays a role in various stages of development and morphogenesis, as well as in angiogenesis and wound healing processes. FGF-1 is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF-1 with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Ligation triggers receptor dimerization, transphosphorylation, and internalization of receptor/FGF complexes.
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