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Description
FITC Mouse Anti-Rat CD45R Antibody (S-3303)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S 3303 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein A Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | CD45 |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; Ptprc |
| Location | Cell membrane, Synapse |
| Accession | P04157 |
| Clone Number | S-3303 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Rt |
Background
CD45R is a critical splice variant of the CD45 protein, belonging to the receptor-type protein tyrosine phosphatase (RPTP) family. It is primarily expressed on the surface of B cells, monocytes, and certain T cell subsets. As a transmembrane glycoprotein, its extracellular region contains domains (A, B, C) encoded by variable exons, forming diverse isoforms (e.g., CD45RA, CD45RB). These domain variations influence glycosylation patterns and ligand-binding properties. The core function of CD45R lies in its intracellular phosphatase domain, which specifically dephosphorylates the C-terminal inhibitory tyrosine residues of Src family kinases (such as Lck and Fyn). This action positively regulates the initiation and activation threshold of lymphocyte receptor signaling pathways, playing a vital role in B cell development, activation, and the fine-tuning of immune responses. Changes in its expression pattern often serve as markers for lymphocyte differentiation and activation status (e.g., CD45RA+ denotes naive T cells), holding significant value in immunology research and the clinical diagnosis of immune-related diseases.
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