Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 16 - Aug 21
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Mouse Anti-Human CD42a Antibody (S-4391)Product Specification Host Mouse Antigen CD42a Synonyms Platelet glycoprotein IX; GP IX; GPIX; Glycoprotein 9; GP9 Location Membrane Accession P14770 Clone Number S 4391 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Fresh human peripheral blood cells Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of
Product Specification
| Host | Mouse |
| Antigen | CD42a |
| Synonyms | Platelet glycoprotein IX; GP-IX; GPIX; Glycoprotein 9; GP9 |
| Location | Membrane |
| Accession | P14770 |
| Clone Number | S-4391 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Fresh human peripheral blood cells |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD42a, also known as glycoprotein IX (GPIX), is an essential subunit of the platelet surface glycoprotein Ib-IX-V complex. This complex serves as the primary receptor for von Willebrand factor (vWF) and plays a central role in platelet adhesion, thrombus formation, and primary hemostasis. CD42a non-covalently associates with other subunits such as glycoprotein Ibα (GPIbα) and glycoprotein Ibβ (GPIbβ) to maintain the structural stability and proper membrane expression of the receptor complex. Upon vascular injury, the CD42a-containing complex rapidly binds exposed vWF, mediating firm platelet adhesion to the subendothelial matrix under high shear stress and initiating downstream signaling that leads to platelet activation and aggregation. Mutations in the CD42a gene (GP9) cause the rare autosomal recessive disorder Bernard-Soulier syndrome, characterized by giant platelets, thrombocytopenia, and a severe bleeding tendency. Furthermore, as a platelet-specific marker, CD42a holds significant value in flow cytometry, quality assessment of platelet transfusion, and research into the pathological mechanisms of thrombotic disorders.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy