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Description
Mouse CD96 Protein, His TagProduct Specification Species Mouse Synonyms T cell surface protein tactile, Cell surface antigen CD96, T cell activated increased late expression protein Accession Q3U0X8 Amino Acid Sequence Protein sequence (Q3U0X8, Val22 Met536, with C His tag)
Product Specification
| Species | Mouse |
| Synonyms | T-cell surface protein tactile, Cell surface antigen CD96, T cell-activated increased late expression protein |
| Accession | Q3U0X8 |
| Amino Acid Sequence | Protein sequence (Q3U0X8, Val22-Met536, with C-His tag) VWEELFNVGDDVYALPGSDINLTCQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWTLYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEPYTQDEHNYTIEIETNRTLEIPCFQNTSSEIPPRFTFSWLVEKDGVEEVLFTHHHHVNNSTSFKGRIRLGGDYRLHLSPVQIQDDGRTFSCHLTVNPLKAWKMSTTVKVFAKPEILMTVENSTMDVLGERVFTCLLKNVFPKANITWFIDGRFLQGNEEGIYITNEEKNCSSGFWELKSVLTRMHSGPSQSNNMTAWCMALSPGPRNKMWNTSSQPITVSFDSVIAPTKHLPTVTGSTLGTQPFSDAGVSPTGYLATPSVTIVDENGLTPDATPQTSNSSMTTKDGNYLEASSGTDAKNSSRAAASSKSGSWPFPFTSPPEWHSLPGTSTGPQEPDSPVSWIPSEVHTSAPLDASLAPHDTIISTTTEFPNVLTTANGTTKIDHGPITSIIVNQPSDGM |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 58.5 kDa Observed MW: 100-130 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | with C-His tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
CD96 (also known as TACTILE) is an immune checkpoint protein belonging to the immunoglobulin superfamily, closely related to TIGIT and CD226 (DNAM-1). It is primarily expressed on natural killer (NK) cells and T cells, where it interacts with its ligand, CD155 (PVR), and to a lesser extent, CD112 (PVRL2). CD96 functions as a co-inhibitory receptor, dampening immune responses by competing with the activating receptor CD226 for the same ligands.
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