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Description
SAPK/JNK Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen SAPK JNK Synonyms Mitogen activated protein kinase 8; MAP kinase 8; MAPK 8; JNK 46; Stress activated protein kinase 1c (SAPK1c); Stress activated protein kinase JNK1; c Jun N terminal kinase 1; JNK1; PRKM8; SAPK1; SAPK1C; MAPK8 Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Synapse Accession P45983 Antibody Type Polyclonal antibody Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive
Product Specification
| Host | Rabbit |
| Antigen | SAPK/JNK |
| Synonyms | Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c (SAPK1c); Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK1; PRKM8; SAPK1; SAPK1C; MAPK8 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus, Synapse |
| Accession | P45983 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, Jurkat, NIH/3T3, mouse brain, C6, rat brain |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Ms |
Background
Stress-activated protein kinases (SAPK)/c-Jun N-terminal kinases (JNK) are members of the mitogen-activated protein kinase (MAPK) family, activated by various environmental stresses such as UV irradiation, inflammatory cytokines, and growth factors. They play crucial roles in regulating cell proliferation, apoptosis, motility, metabolism, DNA repair, and immune responses. The JNK/SAPK pathway involves a three-tiered kinase cascade, with MAPK kinases (MKKs) like MKK4 and MKK7 phosphorylating and activating JNKs. This pathway is essential for cellular adaptation to stress and has been implicated in diseases such as cancer and metabolic disorders.
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