SKU: 77743656767

Mouse Anti-Rat CD45R Antibody (S-3303)

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Description

Mouse Anti-Rat CD45R Antibody (S-3303)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S 3303 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Rt Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date

Product Specification


Host Mouse
Antigen CD45
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; Ptprc
Location Cell membrane, Synapse
Accession P04157
Clone Number S-3303
Antibody Type Mouse mAb
Isotype IgG2b,k
Application FCM
Reactivity Rt
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Background

CD45R is a critical splice variant of the CD45 protein, belonging to the receptor-type protein tyrosine phosphatase (RPTP) family. It is primarily expressed on the surface of B cells, monocytes, and certain T cell subsets. As a transmembrane glycoprotein, its extracellular region contains domains (A, B, C) encoded by variable exons, forming diverse isoforms (e.g., CD45RA, CD45RB). These domain variations influence glycosylation patterns and ligand-binding properties. The core function of CD45R lies in its intracellular phosphatase domain, which specifically dephosphorylates the C-terminal inhibitory tyrosine residues of Src family kinases (such as Lck and Fyn). This action positively regulates the initiation and activation threshold of lymphocyte receptor signaling pathways, playing a vital role in B cell development, activation, and the fine-tuning of immune responses. Changes in its expression pattern often serve as markers for lymphocyte differentiation and activation status (e.g., CD45RA+ denotes naive T cells), holding significant value in immunology research and the clinical diagnosis of immune-related diseases.

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SKU: 77743656767

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Whoknewit'sme
Boise, US
★★★★★ 5
Mini Aussie LOVES
Flavor Name: Peanut Butter, Size: Large, Flavor Name: Peanut Butter, Size: Large
My little Meg loves these chew bones, she sneaks in and steals them from our Golden Retriever and our Great Pyrenees. She chews the orange covering off in minutes and the under bone lasts a few weeks. The dogs steal them from each other all the time, even though I buy them each one. Highly recommend if you have a super chewer, just be mindful the orange cover is easily chewed off.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2024
S
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Shenedra R
Fort Morgan, US
★★★★★ 5
But It
Flavor Name: Peanut Butter, Size: Medium
My fur baby has his fair share of toys, but something about this one he won’t put down. Pieces fall off the ends once they chew on it for a while.
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Reviewed in the United States on June 12, 2026
M
Verified Purchase
Mae
Cuba, US
★★★★★ 5
Love this!
Flavor Name: Peanut Butter, Size: Large
My dog loves these! They're way better than rawhide!
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Reviewed in the United States on May 4, 2026
E
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Esther T
Massapequa, US
★★★★★ 4
DOGS LIKE IT
Flavor Name: Peanut Butter, Size: Large
DOGS LIKE IT
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Reviewed in the United States on June 5, 2026
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Verified Purchase
Jami Lynn
Waukegan, US
★★★★★ 5
A hardy chew toy
Flavor Name: Peanut Butter, Size: Medium, Flavor Name: Peanut Butter, Size: Medium
My dog loves these! I have purchased several. The size is perfect for my 25-pound cockapoo. It’s durable and she chews them for months until they’re prickly and not as fun anymore. The price is reasonable enough and she loves them so well (they’re one of the two chew toys that she likes), so I feel like the cost is worth it. One thing to note is that my dog does chew off tiny bits from the bone. She usually spits them out but has swallowed some bits here and there. There hasn’t been a situation with the swallowed pieces, but I always monitor her as she uses it and would suggest that for other pet owners also. Safety is always key, but we have never had any problems in the two years I’ve been buying them.
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Reviewed in the United States on September 2, 2025

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