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Description
Slug Recombinant Rabbit mAb (S-3177)Product Specification Host Rabbit Antigen Slug Synonyms Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2; SLUG; SLUGH; SNAI2 Location Nucleus Accession O43623 Clone Number S 3177 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample A204, NIH 3T3 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Slug |
| Synonyms | Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2; SLUG; SLUGH; SNAI2 |
| Location | Nucleus |
| Accession | O43623 |
| Clone Number | S-3177 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | A204, NIH/3T3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
Slug protein is a transcription factor that plays a crucial role in various biological processes. It belongs to the Snail family of zinc-finger transcription factors and is highly conserved across different species. Slug is involved in epithelial-mesenchymal transition (EMT), a process where epithelial cells lose their cell-cell adhesion properties and acquire mesenchymal characteristics This. transition is essential during embryonic development for tissue remodeling and organogenesis. In addition, Slug has been implicated in cancer progression, where it can promote tumor invasion and metastasis by downregulating the expression of cell adhesion molecules such as E-cadherin. It also has roles in maintaining stem cell properties and regulating cell survival under stress conditions.
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