SKU: 83017184523

IL-23 R Fc Chimera Protein, Human

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Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
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  • Delivery to the USA:
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 83017184523

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4.5 ★★★★★
Based on 26 reviews
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Verified Purchase
Brenda
Lowell, US
★★★★★ 4
Suave al contacto para restregarle el cuerpo a mi nene
Color: Turtle&bunny
Me a encantado este producto lo único malo que me pasó es que la parte de la esponja se descoció o me tocó que cocerlo para que no se le saliera la esponja, de ahí en fuera muy buen producto
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 23, 2026
R
Reviews since 2022-
Bozeman, US
★★★★★ 5
Made very well!~!
Color: Frog&strawberry, Color: Frog&strawberry
Arrived as pictured. Boxed nice and cute. Suitable to send as a gift or for retail sales. These are not only adorable but wash very well. My grandson and I both like them. He said the strawberry was for me and he took the frog. I normally have to bribe him to bathe but all I have to say is froggy is waiting and he runs in!~!~ I love my strawberry and it really cleans well. Such fun and I'm delighted with them both. The size is perfect and I'm grateful. We have been using them for awhile to and they have held up like new. Worth the cost and priced very fair.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 3, 2026
C
Chill Champ
Chelsea, US
★★★★★ 5
Super Cute Sponges for kids!
Color: Frog&strawberry, Color: Frog&strawberry
This is a pack of super cute kids bath sponges. These are sponges attached to loofahs that have a loop on them and can be hung to dry. These are shaped, One looked like a frog and the other like a strawberry making this pack accommodate both boy and girls. These sponges work very well and feel like they're made of a decent quality. The sponge area is very soft and the loofahs feel well made. These are a perfect size for the kiddos. These do a good job at lathering up the suds for the little ones. These also feel like they have a good durability and don't feel like they're gonna fall apart anytime soon. These are super cute and would make a great gift as well. The value on this is not very expensive. These are affordable especially for gifting. giving this an expected value in my opinion and at the time of this review. Overall, these sponges are super cute and would make a fantastic gifts for little ones. I would have no issues recommending these.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 31, 2026
H
Hambster
Phoenix, US
★★★★★ 5
Very functional, and lots of fun for little kids. Gentle enough for their skin, too.
Color: Frog&strawberry
These are so awesome. Two of them come in a box. There's a frog one and a strawberry one. They are inside individual zip lock bags inside the box. There's a scrubbie/loofa (not a natural one, just the plastic webbing type) on one side, and cloth-covered plushie/sponge on the other side that is the strawberry/frog. My granddaughter loves them. She can use them to clean and scrub herself, just like a big girl, but with a fun sponge/scrubby that she likes, so she always knows that there's a special one that is just hers. They absorb plenty of water and soap, and are good for cleaning their whole body. They are just the right size to fit in an adult hand, so a little big for solo use by a little hand, but there are plenty of bits to grab onto on either side, so it's not hard for a little kid to hang onto them. The loofah/scrubby side is well made, although it will become big and loose as those things always do if you pull on them too much. The sponge/toy side is very soft, and definitely gentle enough for a small child's skin. My only dislike is the small loop for hanging it on a hook in the shower. The little loop is just tiny and hard to separate, so it's difficult to get it onto a hook so it can hang and dry out in between uses. It would have been very easy to make the loop longer and more functional, so I'm not sure why they didn't. Other than that one, minor inconvenience, this is a great product.
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Reviewed in the United States on February 26, 2026
R
RachieG
Fort Morgan, US
★★★★★ 5
Adorable scrubbie
Color: Turtle&bunny
Durable sponge made with quality material. Great value for price, soap lathers well and no signs of wear and tear after using for a month. Not too rough on the skin, plus you can’t beat the adorable turtle design
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 15, 2026

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