SKU: 85129052765

IL-12 Protein, Human

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Description

IL-12 Protein, HumanProduct Specification Species Human Synonyms Interleukin 12 subunit alpha; IL 12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL 12 subunit p35; NK cell; IL12A ; NKSF1 stimulatory factor chain 1 Accession P29459P29460 Amino Acid Sequence p40: Ile23 Ser328 p35: Arg23 Ser219 Expression System CHO Molecular Weight P40: 34. 7kDa (Reducing) ; P35: 22. 5kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag

Product Specification


Species Human
Synonyms Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell; IL12A ; NKSF1 stimulatory factor chain 1
Accession P29459、P29460
Amino Acid Sequence

p40:Ile23-Ser328 p35:Arg23-Ser219

Expression System CHO
Molecular Weight

P40:34.7kDa (Reducing) ;P35:22.5kDa (Reducing)

Purity

>95% by SDS-PAGE

Endotoxin <1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4.

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1. Airoldi, I. et al. (2000) Journal of Immunology 165:6880.

2. Wolf, S.F. et al. (1991) Journal of Immunology 146:3074.

3. Gearing, D. et al. (1991) Cell 66:9.

4. Merberg, D. et al. (1992) Immunology Today 13:78.

5. Gubler, U. et al. (1991) Proc. Natl. Acad. Sci. 88:4143.

Background

IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

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Exchange/Return Notes
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SKU: 85129052765

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rms
Whiting, US
★★★★★ 5
Nice shirt, great price.
Fit Type: Regular Fit, Color: White, Size: Medium
Worn it twice and I find it very comfortable. I wear it outside and casually to protect my arms and neck from the sun and find it more comfortable than a long sleeve t-shirt. The price is comparable. If I was to wear it to the office it would have to be ironed. I bought one shirt to try it and I will be buying more.
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Reviewed in the United States on May 8, 2026
A
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Anthony Carabello
Bozeman, US
★★★★★ 4
Nice shirt!
Fit Type: Regular Fit, Color: White, Size: X-Large
I added one of these shirts to another order just to see if they were any good. I was pleasantly surprised by the quality. It fits perfectly and looks pretty nice for a low cost casual dress shirt. Materials seem decent quality. Comfortable, soft fabric. Didn’t shrink too much in the washer and dryer. We’ll see how it holds up long term but so far so good
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Reviewed in the United States on November 12, 2025
M
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madison
Lexington, US
★★★★★ 5
nice quality
Fit Type: Regular Fit, Color: White, Size: Small
nice quality shirt. bought this just so i had at least one nice white button down and it's great. fits well and is a nice white color.
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Reviewed in the United States on April 11, 2026
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Jerry
Grantham, US
★★★★★ 5
A perfect white work shirt.
Fit Type: Regular Fit, Color: White, Size: Medium
Thick, durable, iron exquisitely and the fit is spot on. Perfect white work shirt. I have a grey shirt too, the quality is the same.
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Reviewed in the United States on March 4, 2026
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Blusher
Draper, US
★★★★★ 3
Right fit
I love this shirt it was nice and bright when I got it after a few wash it started to fade out a bit was a perfect fit for a medium built person 5’7 I still would recommend this product they are really nice and thick
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Reviewed in the United States on September 14, 2025

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