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Description
CEA Recombinant Rabbit mAb (SDT-098-41)Product Specification Host Rabbit Antigen CEA Synonyms Carcinoembryonic antigen related cell adhesion molecule 5, Carcinoembryonic antigen, CD66e Immunogen Recombinant Protein Location Secreted, Membrane Accession P06731 Clone Number SDT 098 41 Antibody Type Rabbit mAb Application CLIA, Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize CEACAM 1, CEACAM 6, CEACAM 8 Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Physical
Product Specification
| Host | Rabbit |
| Antigen | CEA |
| Synonyms | Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen, CD66e |
| Immunogen | Recombinant Protein |
| Location | Secreted, Membrane |
| Accession | P06731 |
| Clone Number | SDT-098-41 |
| Antibody Type | Rabbit mAb |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize CEACAM-1, CEACAM-6, CEACAM-8 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH 7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| N/A |
Background
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. CEA are glycosyl phosphatidyl inositol (GPI) cell-surface-anchored glycoproteins whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells. Immunologically they are characterized as members of the CD66 cluster of differentiation. The proteins include CD66a, CD66b, CD66c, CD66d, CD66e (CEA), CD66f.Consequently, CEA is usually present at very low levels in the blood of healthy adults (about 2–4 ng/mL). The normal reference interval of serum CEA in Chinese adults was less than 5μg/L. However, the serum levels are raised in some types of cancer. CEA is an important tumor marker for colorectal and some other carcinomas. CEA is not a typical specific tumor marker, which needs to be combined with other indicators in clinical diagnosis to improve the specificity and sensitivity of detection.
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