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Description
Alexa Fluor® 647 Rat Anti-Mouse CD199 Antibody (S-R715)Product Specification Host Rat Antigen CD199 Synonyms C C chemokine receptor type 9; C C CKR 9; CC CKR 9; CCR 9; Chemokine C C receptor 10; CDw199; Cmkbr10; Ccr9 Location Cell membrane Accession Q9WUT7 Clone Number S R715 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse thymocytes Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rat |
| Antigen | CD199 |
| Synonyms | C-C chemokine receptor type 9; C-C CKR-9; CC-CKR-9; CCR-9; Chemokine C-C receptor 10; CDw199; Cmkbr10; Ccr9 |
| Location | Cell membrane |
| Accession | Q9WUT7 |
| Clone Number | S-R715 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD199, also known as CCR9, is a member of the G protein-coupled receptor (GPCR) family and functions as a chemokine receptor. It is a ~42 kDa seven-transmembrane protein primarily involved in T cell development in the thymus and gut-associated immune responses. CCR9 is expressed on T lymphocytes and is upregulated in response to retinoic acid, which is produced by dendritic cells, facilitating the migration of T cells to gut-associated tissues. Its specific ligand is CCL25 (TECK), and the interaction between CCR9 and CCL25 plays a crucial role in the recruitment and maturation of thymocytes. Additionally, CCR9 is differentially expressed in T lymphocytes of the small intestine and colon, suggesting its involvement in specialized immune responses within the gastrointestinal tract.
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