SKU: 86918994746

SS18-SSX Recombinant Rabbit mAb (SDT-4202)

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Description

SS18-SSX Recombinant Rabbit mAb (SDT-4202)Product Specification Host Rabbit Antigen SS18 SSX Synonyms SYT SSX1; SS18 SSX1 fusion; SSX1 SSXT fusion Location Nucleus Accession A4PIV8 Clone Number SDT 4202 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt

Product Specification


Host Rabbit
Antigen SS18-SSX
Synonyms SYT-SSX1; SS18/SSX1 fusion; SSX1/SSXT fusion
Location Nucleus
Accession A4PIV8
Clone Number SDT-4202
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:500 Hu

Background

The SS18-SSX fusion protein is the defining oncogenic driver of synovial sarcoma, arising from the chromosomal translocation t(X;18)(p11;q11) that fuses the SS18 gene on chromosome 18 with SSX1, SSX2, or rarely SSX4 on the X chromosome, producing a chimeric protein in which the C-terminal 8 amino acids of SS18 are replaced by 78 residues from SSX; this fusion retains the N-terminal SNH domain of SS18 that mediates incorporation into SWI/SNF (BAF) chromatin-remodeling complexes, but the SSX moiety recruits polycomb repressive complexes (especially PRC1.1 via KDM2B) and binds H2AK119ub-rich regions, thereby hijacking BAF targeting to aberrantly activate developmentally repressed genes, evict the tumor-suppressive BAF47 (SMARCB1/INI1) subunit, and globally reprogram the epigenetic landscape to enforce malignant transformation.

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SKU: 86918994746

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4.6 ★★★★★
Based on 8 reviews
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Product Reviews
R
Verified Purchase
Richard C. Jones
Omaha, US
★★★★★ 3
Three Stars
Format: Paperback
Only purchased this because I have the action figure
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 7, 2014
M
MM
Grantham, US
★★★★★ 4
A fairly decent super hero romp
Format: Paperback
If Mister Terrific suffers from any one flaw it is that he is incredibly generic. Nothing about this book was particularly offensive and it provided for some fairly good reads but the villains Terrific goes up against are hardly that. Despite this weakness, I found the series to be a fairly good read and while the major ongoing storylines were clearly cut short by the title's untimely demise, the ending satisfactorily led into the current status quo for Mister Terrific on Earth-2. Whether his presence there becomes relevant or not remains to be seen (particularly with the depature of Earth-2 writer James Robinson) but as things stand now, Mind Games still seems to be valuable background reading for Earth-2 and also lays a bit of ground work for the plot in World's Finest, meaning that Mister Terrific is nicely connected to the two current Earth-2 based titles. The pace of the book is fairly decent, with several short story arcs that see Mister Terrific facing different villains and an ongoing plot throughout that deals with Terrific's secret identity and the issues he is dealing with as the CEO of a Fortune 500 company. The writing is not always sharp but the supporting cast is fairly solid and its a tragedy that we probably won't see some of these characters again. Terrific himself has enjoyable, if somewhat illogical, inner monologue that typically involves him thinking through a problem and while the science is (often) fuzzy, Wallace does a good job of showing how science and tech form the basis of Mister Terrific's powerset. I would characterize this book as a solid B-list entry. Fans of the character may appreciate it as well as readers looking for something a little different but it is by no means a must-read. I'll be keeping it on my shelf as an important book for World's Finest and Earth-2 (both of which I have pulled since issue #1) however. If you can get your hands on this trade (or its related single issues) for a modest price, it provides a decent couple of hours of reading. It is a pity that nothing stands out particularly well but I appreciated that so much seemed to happen in only eight issues compared to some of the tedious extended plots of other comics.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 7, 2013
B
Verified Purchase
Bruce Gravlin
Chelsea, US
★★★★★ 5
Silver Age Batman time trip
Format: Hardcover
Fun book. I was born at the very beginning of the Silver Age and had older brothers, so I was reading by four, and had great reading material available.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 28, 2025
R
Verified Purchase
Ringo
Charlottesville, US
★★★★★ 5
A Baby Boomer dream come true!
Format: Hardcover
I love the Golden Age omnibus Batman series. However, for many of us baby boomers the Silver Age is what we’ve been craving. Those were exciting days back then, looking for the new issue of Batman or Detective Comics on the newsstand. One of the previous reviewers is correct, though, there are some missing issues between the last golden age omnibus and this, the first silver age omnibus, that need to be put into book form at some point. I certainly hope we get them. But more than anything I am really hoping that this will not be the first and last silver age omnibus. By my count, there are almost exactly the issues needed to make three more silver age volumes before we get to the “new look Batman,” which started in mid 1964. And frankly, I hope they continue on with a “new look” omnibus series as well. This first volume, though, was absolutely beautiful! The re-creation of these old panels is breathtaking. When you go back and look at the old dot matrix original issues and compare them to the re-printings contained within this omnibus…well…there simply is no comparison. Batman, the Silver Age Omnibus Volume One is practically as good as it gets. The only thing more I could have wished for would have been the inclusion of the old advertisements that decorated the pages of the original issues. Other than that, this book is perfect. Wow!
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Reviewed in the United States on December 27, 2022
A
Verified Purchase
Amazon Customer
Boise, US
★★★★★ 5
Quality Reproduction of Artwork
Format: Hardcover
The book looks great and includes a massive amount of content; however, this is DC Batman Silver Age stories verses Marvel Silver Age stories. It was hard getting through some of the stories and did not make it through the entire book. I think I would have enjoyed the stories that came before this collection and/or the great Neal Adams Batman content. This era of batman stories was just silly and boring. But just my opinion.
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Reviewed in the United States on November 5, 2024

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