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Description
IL-6 Protein, MouseProduct Specification Species Mouse Synonyms Interleukin 6 protein, IL 6 protein; Interleukin 6, IL 6, B Cell Hybridoma Growth Factor, Interleukin HP 1, Il6, Il 6 Accession P08505 Amino Acid Sequence Phe25 Thr211 Expression System E. coli Molecular Weight 22kDa Purity 95% by SDS PAGE&RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 1x PBS, pH 7. 4 Reconstitution Reconstitute at 0. 1
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-6 protein, IL-6 protein;Interleukin-6, IL-6, B-Cell Hybridoma Growth Factor, Interleukin HP-1, Il6, Il-6 |
| Accession | P08505 |
| Amino Acid Sequence |
Phe25-Thr211 |
| Expression System | E.coli |
| Molecular Weight |
22kDa |
| Purity | ＞95% by SDS-PAGE&RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer |
1x PBS, pH 7.4 |
| Reconstitution |
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Cold Spring Harb Perspect Biol. 2014 Sep 4;6(10):a016295. |
Background
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis, Which promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses. Dysregulation of IL-6-type cytokine signalling contributes to the onset and maintenance of several diseases, such as rheumatoid arthritis, inflammatory bowel disease, osteoporosis, multiple sclerosis and various types of cancer (e.g. multiple myeloma and prostate cancer).
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