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Description
MTBR-Tau243 (225-242) Recombinant Rabbit mAb (SDT-2033-15)Product Specification Host Rabbit Antigen MTBR Tau243 Synonyms microtubule binding region containing residue 243 Immunogen Synthetic Peptide Accession P10636 8 Clone Number SDT 2033 15 Antibody Type Recombinant mAb Isotype IgG Application ELISA, Competitive ELISA Reactivity Hu Cross Reactivity No cross reactivity against Tau peptide (aa225 243), it shows good binding ability with Tau peptide (aa225 242). Purification Protein A Concentration 2 mg ml
Product Specification
| Host | Rabbit |
| Antigen | MTBR-Tau243 |
| Synonyms | microtubule-binding region containing residue 243 |
| Immunogen | Synthetic Peptide |
| Accession | P10636-8 |
| Clone Number | SDT-2033-15 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA, Competitive ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against Tau peptide (aa225-243), it shows good binding ability with Tau peptide (aa225-242). |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
MTBR-Tau243 is a segment of the tau protein located within its microtubule-binding region (MTBR), specifically spanning the tau microtubule-binding region containing residue 243. This protein fragment has garnered significant attention as a specific biomarker for tau tangle pathology in Alzheimer's disease. Research has shown that MTBR-Tau243 levels in cerebrospinal fluid (CSF) and plasma are closely correlated with the presence and progression of neurofibrillary tangles, which are a hallmark of Alzheimer's. Unlike other tau biomarkers such as phosphorylated tau species, which are more related to amyloid plaques, MTBR-Tau243 is strongly associated with tau aggregates and cognitive impairment. Its detection in body fluids can help distinguish Alzheimer's disease from other neurodegenerative disorders and may serve as a valuable tool for monitoring disease progression and evaluating the efficacy of tau-targeted therapies.
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