Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 11 - Aug 16
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
NOX2/gp91phox Recombinant Rabbit mAb (S-2974-75)Product Specification Host Rabbit Antigen NOX2 gp91phox Synonyms NADPH oxidase 2; CGD91 phox; Cytochrome b(558) subunit beta (Cytochrome b558 subunit beta); Cytochrome b 245 heavy chain; Heme binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; CYBB Immunogen Synthetic Peptide Location Cell membrane Accession P04839 Clone Number S 2974 75 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu
Product Specification
| Host | Rabbit |
| Antigen | NOX2/gp91phox |
| Synonyms | NADPH oxidase 2; CGD91-phox; Cytochrome b(558) subunit beta (Cytochrome b558 subunit beta); Cytochrome b-245 heavy chain; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; CYBB |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P04839 |
| Clone Number | S-2974-75 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu |
Background
NOX2/gp91phox, encoded by the CYBB gene on chromosome X, is a 570-amino-acid, ~91 kDa glycosylated flavohemoprotein that forms the catalytic core of the phagocyte NADPH oxidase complex; its N-terminal six-transmembrane α-helical domain anchors it to the plasma membrane, binds p22phox, and ligates two non-identical hemes that sequentially transfer electrons across the membrane, while its C-terminal cytoplasmic tail docks NADPH and FAD, enabling a four-step redox cascade that reduces extracellular O₂ to microbicidal superoxide (O₂⁻), thereby driving the respiratory burst essential for killing invading pathogens; genetic loss-of-function mutations in gp91phox cause chronic granulomatous disease, whereas its overactivation contributes to oxidative stress implicated in atherosclerosis, hepatic fibrosis, and other inflammatory disorders.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy