SKU: 86464046556

IBUTAMOREN (MK-677) Powder, 1gr

Sale price$53.99 Regular price$59.99
Save 10%

Pay in installments of $15.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 20 - Jul 25

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

IBUTAMOREN (MK-677) Powder, 1grMK 677 is a long acting agonist of the ghrelin receptor and stimulates the production of human growth hormone (GH). This spiroindoline sulfonamide is also known as Ibutamoren, MK 677, L 163,191 and was formerly referred to as Oratrope. In a study conducted by Jacks et al., published in Endocrinology in 1997, 8 beagles were administered doses of MK 677 of 0. 25 mg kg. This resulted in GH levels being 5. 3 times higher than the original baseline levels.

MK-677 is a long-acting agonist of the ghrelin receptor and stimulates the production of human growth hormone (GH). This spiroindoline sulfonamide is also known as Ibutamoren, MK-677, L-163,191 and was formerly referred to as Oratrope.

In a study conducted by Jacks et al., published in Endocrinology in 1997, 8 beagles were administered doses of MK-677 of 0.25 mg/kg. This resulted in GH levels being 5.3 times higher than the original baseline levels. At a dose of 0.5 mg/kg, GH levels increased 9 times, and at a dose of 1 mg/kg, they increased almost 16 times (15.8 times the baseline value). It's important to emphasize that these doses were administered orally, rather than via intravenous or intramuscular injection.

The insulin-like growth factor remained elevated by 30% for 8 hours, indicating that MK-677 is a long-acting compound, at least in beagles. GH levels also remained elevated for up to 6 hours. The authors of the study noted that cortisol levels also increased but to a lesser extent than GH levels.

MK-677 is not just a GH secretagogue but also an orally active agonist of the ghrelin receptor. This means that it has an effect on ghrelin receptors. Zhang et al. explain that the "hunger hormone" ghrelin activates the ghrelin receptor (GHSR) to stimulate food intake and GH release, as well as to regulate reward signaling.

Besides its role in signaling hunger, it also influences various other physiological processes including stress, glucose metabolism, body weight, cognition, intestinal motility, food craving, adiposity, and even pain perception.

An extensive study by Zhang and his team on the chemical structure of MK-677 showed that this compound mimics the first four N-terminal residues of ghrelin, including the octanoyl group that binds to the lower region of the ligand-binding pocket. More details can be found in their research paper: Link to paper

For more information on the various target organs of ghrelin, see the following image: Link to image

In another study, published in the International Journal of Molecular Sciences, Jeong et al. administered MK-677 to mice genetically predisposed to overproducing amyloid beta-peptide (Aβ). This protein is responsible for the plaques and tangles observed in the brains of Alzheimer's patients. The mice received MK-677 injections for ten days at doses of 0.1, 1, and 3 mg/kg. The last two groups showed increased food intake, especially at the 3 mg/kg dose. However, at the end of the ten days, there was no significant difference in body weight between the different dosage groups.

The study showed that treatment with MK-677 resulted in reduced Aβ deposition, fewer neuronal and synaptic losses, and reduced glial changes in the cortical layers of the brain. Furthermore, the researchers concluded that MK-677 also reduced neuroinflammation and neurodegeneration associated with Aβ.

DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary use. Please use with our DISCLAIMER before ordering.

Data Sheet

MK-677 (Ibutamoren Mesylate) – Powder, 1g

Application A potent, non-peptide ghrelin receptor agonist
CAS 159752-10-0
Molar Mass 528.662 g/mol
 Chemical Formula C27H36N4O5S
IUPAC Name 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid
Synonyms Ibutamoren, MK-677, MK-0677, MK677, L-163,191, L163191, Nutrobal
Storage Minimize open air exposure, store in a cool dry place. This product is hygroscopic. It can absorb moisture from the air and form hard clumps.
Solubility Soluble in Water, Ethanol, PEG400
Organoleptic Profile Beige fine powder, hygroscopic, acrid odor
Physical Form Solid
Specification ≥98%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 86464046556

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.9 ★★★★★
Based on 26 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
B
Verified Purchase
billy
Whiting, US
★★★★★ 5
My dog is a toy destroyer
Color: Consuela the Cactus - Large, Size: Large Dog, Color: Consuela the Cactus - Large, Size: Large Dog
I’ve had a hard time trying to find toys that my dog, Zara loves because she’s actually very picky. Ive gotten plenty of Kong toys that are well known to be indestructible but she wants nothing to do with them. Then I got her ropes and that seemed to be good for a while until she was getting sick in the middle of the night from eating all of the string. Stuffed toys aren’t good because she’ll rip them within seconds and eat all of the stuffing. I felt like I’ll never score the perfect toy for her. I found the three layered cactus toy and decided to give it a go. It’s clearly designed to be ripped and destroyed to get the ball in the middle which is actually really cute and fun to see all of the layers. The cactus arms have stuffing and of course that’s the first thing she went for and ate. I had to watch her and make sure I took the stuffing away before she ate it. And before I knew it, she ate half of the first layer fabric lol once she got through the first layer, all she’s been doing is walking around the house with the toy in her mouth. But now she’s tired and passed out on the couch from all of the fun. This toy won’t last long with a toy destroyer but it sure does give them something to do and it’s a cute toy. I do recommend!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 26, 2024
K
Verified Purchase
Klara Gengler
Bozeman, US
★★★★★ 5
Last a while. Will be buying more toys soon.
Color: Consuela the Cactus - Large, Size: Large Dog
Best dog toy I have ever bought. I have three dogs, two at the time I bought this toy. It took them over a year to break through the first layer. The flower comes off first so be careful your dog doesn't swallow it. It still has the second layer so it still looks like a cactus. No stuffing to clean up when they tear into it, which makes it far less messy than other toys. One of my dogs is obsessed with fetch so I use it like a ball inside. The oval shape makes it hard to ensure when it bounces that it will bounce straight. It's bounced into walls and other stuff that I wasn't intending it to hit. Not much of a squeak so I can let them play with it for hours and I don't get annoyed with the noise. Great toy that lasts a while.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 25, 2025
C
Verified Purchase
Cassie
Chelsea, US
★★★★★ 5
Nice Value
Color: Consuela the Cactus - Large, Size: Large Dog
Very cute! Its soft and feels like it is well made. It is a heavier toy and a tougher one. Not a plush toy. I will order again for our older dogs. Nice value for sure!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 11, 2026
B
Verified Purchase
Blakely McAllister
Omaha, US
★★★★★ 5
Great toy for our best boys!
Color: Consuela the Cactus - Large, Size: Large Dog
You can never go wrong with BarkBox toys and this was no exception. Our dogs like toys that have squeakers and that they can tear into. This style of toy fits the bill. The design is cute as well. I’ve had this in the house for months and, while it’s definitely seen better days, it’s still intact and they haven’t gotten to the inner layer. (Not for want of trying.) The perfect type of toy for our fur babies.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 10, 2026
A
Verified Purchase
Amazon Customer
West Palm Beach, US
★★★★★ 5
Survives 7 months so far.
Color: Christmas Consuela, Size: Large Dog
It is still intact after nearly 7 months of constant play. My blue heeler normally destroys toys in just a few weeks. Consuela has exceeded expectations of survival with an extremely chewy, destruction prone dog.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 6, 2026

recommand products