SKU: 87097093269

Hista Clear - DAO Enzyme (60 tablets)

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Description

Hista Clear - DAO Enzyme (60 tablets)NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food derived histamine in the digestive tract. Our bodies are complex, and there is usually more at play than we think. What most dont take into consideration when addressing histamine related

NEW: Now in NEW packaging

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  

Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here!

Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.

 

Clinical Applications
  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
Description:


Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*

Discussion:

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]

Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]

Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]

Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]

Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*

Read our article: Low Histamine Diet: The High Histamine Foods List

Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.

Video:


Directions:

Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.


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SKU: 87097093269

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Anthony
Bozeman, US
★★★★★ 5
Solid bamboo board set for the price
Color: Carbonized, Size: 3-piece
This bamboo cutting board set has been a nice addition to my kitchen. I like having different sizes available, and I especially appreciate being able to reduce how often I use plastic cutting boards. Mine did have a strong odor at first, but after washing them and letting them air out, that went away. They also seem good for the price
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Reviewed in the United States on May 31, 2026
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Teresa
San Leandro, US
★★★★★ 5
Wood cutting boatds
Color: Carbonized, Size: 3-piece
These are great cuting boards. I love the different sizes. Great quality product, easy to use, easy to clean, sturdy, bamboo material is great.
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Reviewed in the United States on May 29, 2026
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Davejayhawk
Lowell, US
★★★★★ 4
Awesome Boards….BUT the Smell!!!!
Color: Carbonized, Size: 3-piece
I’d love to give these 5 stars, they are heavy, well made, smooth, deep juice grooves, just nice….but the smell! I washed them, then used vinegar on them, set them outside over night, washed them again….its better but still present. I’d love some guidance on this. I’m hoping it goes away in a few days. It’s like a very strong woodsy smell that actually made my whole kitchen smell like these boards! Edit: Ok, here's what I did. Washed, let dry, coated and scrubbed with apple cider vinegar, set them in a high air flow area for 24 hours (I put mine outside on the patio over night), washed and scrubbed again, let dry, scrubbed with lemons and salt, let dry, washed again. Finally, there is still a slight smell if you push them against your nose but that seems to be fading as well. So, great boards if you want to go stubbornly go through the smell removal process. I don't think it's a chemical smell, I think it's processed bamboo that is shrink wrapped in air tight packaging too soon after manufacturing. Anyway, I'll move this to 4 stars....but lots of work involved here!
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Reviewed in the United States on May 25, 2026
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Shannon Latham
New York, US
★★★★★ 5
Obsessed with these boards!!
Color: Carbonized, Size: 3-piece
I love these cutting boards! It’s one of those items you don’t even know you need until you get them. Three perfect smaller sizes that can be used for so many different serving ideas. Great quality, great price. Definitely worth the buy!!!!
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Reviewed in the United States on May 24, 2026
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BF J.V.
Lowell, US
★★★★★ 5
Economical and descent for price
Color: Carbonized, Size: 3-piece, Color: Carbonized, Size: 3-piece
Pleased with price, style, color, and the 3 sizes of these carbonized bamboo cutting boards. Based on the reviews had the expectation of the "smell", which is the oil used to seal the cutting boards. (I suspect linseed oil was used based on the lingering smell, as the off-gasing process is longer. It's also cheaper than Tung oil and food grade mineral oil.) I work with wood and various oil sealants so the smell is a non-issue. As there are natural ways to speed that process up and minimize the smell. In addition, I will be using fractionated coconut oil or food grade mineral oil to seal cutting boards on a regularly basis (monthly or more frequent). As we live in a dry climate, hard water, and frequent use. Appreciate the other reviews which lead to our purchase and reasonable expectation of these cutting boards.
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Reviewed in the United States on May 28, 2026

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