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Description
NT-4 Protein, MouseProduct Specification Species Mouse Antigen NT 4 Synonyms neurotrophic factor 4, neurotrophic factor 5, neurotrophin 4; Neurotrophin 4 Accession Q80VU4 Amino Acid Sequence Gly80 Ala209 Expression System E. coli Molecular Weight 16kDa Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 500mM NaCl, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to
Product Specification
| Species | Mouse |
| Antigen | NT-4 |
| Synonyms | neurotrophic factor 4, neurotrophic factor 5, neurotrophin 4;Neurotrophin-4 |
| Accession | Q80VU4 |
| Amino Acid Sequence | Gly80-Ala209 |
| Expression System | E.coli |
| Molecular Weight | 16kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 500mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Cheryl L Stucky 1, Jung-Bum Shin, Gary R Lewin. Neurotrophin-4: a survival factor for adult sensory neurons. Curr Biol. 2002 Aug 20;12(16):1401-4. |
Background
Neurotrophin 4 (NT-4) is a neurotrophic factor which supports the survival and outgrowth of sensory neurons from embryonic chicken dorsal root ganglia, but has no significant effect on embryonic day 8 sympathetic ganglia1. It has a strong survival/proliferative action on NIH 3T3 cells expressing trkB but little activity on 3T3 cells expressing trkA. NT-4 was originally identified in Xenopus and viper, and was subsequently identified in rat and humans. Neurotrophin 4 is the least studied member of the neurotrophin family. Genetic knockout of NT4 does not result in loss of any DRG sensory neurons, although this factor does influence survival of spinal motor neurons. NT4 is expressed in muscle, and its expression is regulated by activity of innervating motor neurons, which increase its production, thereby providing trophic support to those innervating neurons. This provides an excellent example of bidirectional communication between the target and the afferent neurons, in which the activity of the innervating neurons and the release of trophic factor from the target influence each other to fine-tune the synaptic connections.
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