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Description
Alexa Fluor® 647 Armenian hamster Anti-Mouse CD95 Antibody (S-R535)Product Specification Host Armenian hamster Antigen CD95 Synonyms Tumor necrosis factor receptor superfamily member 6; Apo 1 antigen; Apoptosis mediating surface antigen FAS; FASLG receptor; Apt1; Tnfrsf6; Fas Location Cell membrane Accession P25446 Clone Number S R535 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample C57BL 6 mouse thymocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor
Product Specification
| Host | Armenian hamster |
| Antigen | CD95 |
| Synonyms | Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; Apt1; Tnfrsf6; Fas |
| Location | Cell membrane |
| Accession | P25446 |
| Clone Number | S-R535 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD95, also known as Fas or APO-1, is a 48 kDa type-I transmembrane receptor of the TNF-receptor superfamily that, upon trimerization by its cognate ligand CD95L (FasL), assembles the death-inducing signaling complex (DISC) by recruiting the adaptor FADD and procaspase-8/10, triggering a caspase cascade that culminates in apoptosis, thereby governing immune homeostasis, peripheral tolerance, and elimination of infected or oncogenic cells, while dysregulation of this pathway contributes to autoimmune lymphoproliferative syndrome, cancer immune evasion, and resistance to chemotherapy.
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Exchange/Return Notes
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