Pay in installments of $53.75 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 10 - Aug 15
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotinylated Nucleolin/NCL His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms Protein C23 Accession P19338 1 Amino Acid Sequence Val2 Glu710 with His&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 90 100kDa (Reducing) Purity 85% by SDS PAGE Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | Protein C23 |
| Accession | P19338-1 |
| Amino Acid Sequence | Val2-Glu710 with His&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-100kDa (Reducing) |
| Purity | ＞85% by SDS-PAGE |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Yang L, Niu K, Wang J, Shen W, Jiang R, Liu L, Song W, Wang X, Zhang X, Zhang R, Wei D, Fan M, Jia L, Tao K. Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD. J Hepatol. 2024 Oct;81(4):651-666. |
Background
Nucleolin (NCL) is a crucial multifunctional nucleolar protein in eukaryotic cells, possessing nucleo-cytoplasmic shuttling capability. Its three distinctive structural domains enable it to induce chromatin decondensation by binding to histone H1 and to specifically recognize RNA sequences (with higher affinity for 5'-UUAGGG-3' repeats than their DNA counterparts). This protein not only participates in fundamental biological processes such as ribosome biogenesis, pre-rRNA transcription and processing, and transcriptional elongation regulation, but is also extensively involved in cell proliferation, apoptosis regulation, and stress response. Under pathological conditions, through its roles in tumorigenesis and viral infection, nucleolin has emerged as a significant potential target for anti-tumor and anti-viral therapies.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy