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Description
Man6P Recombinant Rabbit mAb (S-2745)Product Specification Host Rabbit Antigen Man6P Synonyms M6P; mannose 6 phosphate; N glycosylation Clone Number S 2745 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Human brain, mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | Man6P |
| Synonyms | M6P; mannose 6-phosphate; N-glycosylation |
| Clone Number | S-2745 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human brain, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:250 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
Mannose 6-phosphate (M6P) is a critical glycosylation marker primarily involved in the Golgi processing of lysosome-targeted proteins. After synthesis in the rough endoplasmic reticulum, the oligosaccharide chains of these proteins undergo phosphorylation to generate the M6P signal. This signal is then recognized and bound by M6P receptors (MPRs) on the Golgi membrane, facilitating vesicular transport to deliver the proteins to lysosomes. This mechanism is essential for the proper sorting of lysosomal enzymes. Dysfunction in this pathway (e.g., defective M6P generation or receptor mutations) can lead to lysosomal storage disorders, such as I-cell disease. The discovery of the M6P pathway has advanced the understanding of intracellular protein sorting and metabolic diseases, and it is also being explored for targeted delivery applications in gene therapy.
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