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Description
Lipocalin-2/NGAL Recombinant Rabbit mAb (S-2279-72)Product Specification Host Rabbit Antigen Lipocalin 2 NGAL Synonyms Neutrophil gelatinase associated lipocalin; 25 kDa alpha 2 microglobulin related subunit of MMP 9; Oncogene 24p3; Siderocalin; p25; HNL; LCN2 Immunogen Synthetic Peptide Location Secreted Accession P80188 Clone Number S 2279 72 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample COLO 205, SW480, A431 Purification Protein A Concentration 0. 5
Product Specification
| Host | Rabbit |
| Antigen | Lipocalin-2/NGAL |
| Synonyms | Neutrophil gelatinase-associated lipocalin; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Oncogene 24p3; Siderocalin; p25; HNL; LCN2 |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P80188 |
| Clone Number | S-2279-72 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | COLO 205, SW480, A431 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000-1:2000 | Hu |
Background
Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is a multifunctional protein that belongs to the lipocalin family. It is primarily expressed in neutrophils and certain epithelial cells. NGAL plays a crucial role in various biological processes, including iron homeostasis, where it binds and sequesters iron-loaded bacterial siderophores to inhibit bacterial growth, thus contributing to the immune defense mechanism. Additionally, it is involved in cellular differentiation, proliferation, and apoptosis. In clinical contexts, NGAL has emerged as a biomarker for early detection of acute kidney injury, as its levels in urine and blood can rise rapidly in response to renal ischemia or nephrotoxic injury. Furthermore, it has been implicated in the progression of several cancers, where it may influence tumor growth, metastasis, and response to therapy, making it a potential target for cancer diagnostics and treatment.
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