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Description
SEMA5A Recombinant Rabbit mAb (S-2560-24)Product Specification Host Rabbit Antigen SEMA5A Synonyms Semaphorin 5A; Semaphorin F (Sema F); SEMAF Immunogen Synthetic Peptide Location Membrane Accession Q13591 Clone Number S 2560 24 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample A549, U 87 MG, HaCaT, A431, mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | SEMA5A |
| Synonyms | Semaphorin-5A; Semaphorin-F (Sema F); SEMAF |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q13591 |
| Clone Number | S-2560-24 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A549, U-87 MG, HaCaT, A431, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Rt |
Background
SEMA5A (Semaphorin-5A) is a transmembrane glycoprotein encoded by the SEMA5A gene that belongs to the class 5 semaphorin subfamily, featuring an extracellular sema domain, seven thrombospondin type-1 repeats (TSR1-7), and a short cytoplasmic tail. Originally identified as an axon guidance cue, SEMA5A is bifunctional, either promoting or inhibiting axon growth and cell migration depending on context, and it binds plexin-B3 to regulate neural circuit development in the retina, hippocampus, cortex, and spinal cord. Beyond the nervous system, SEMA5A exhibits context-dependent roles in tumorigenesis (e.g., promoting pancreatic cancer invasion but suppressing lung adenocarcinoma proliferation and migration) and in immune modulation (e.g., driving inflammation in rheumatoid arthritis and chronic urticaria). Importantly, dysregulation or mutation of SEMA5A is genetically linked to neurodevelopmental disorders such as autism spectrum disorder, intellectual disability, and Parkinson’s disease, with reduced expression observed in autistic brains.
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