Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 11 - Aug 16
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Merlin Recombinant Rabbit mAb (S-2331-22)Product Specification Host Rabbit Antigen Merlin Synonyms Moesin ezrin radixin like protein; Neurofibromin 2; Schwannomerlin; Schwannomin; SCH; NF2 Immunogen Synthetic Peptide Location Nucleus, Cell projection Accession P35240 Clone Number S 2331 22 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, PC 3, MCF7, HepG2, MEF, mouse brain, rat brain Predicted Reactivity Bb Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | Merlin |
| Synonyms | Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; SCH; NF2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Cell projection |
| Accession | P35240 |
| Clone Number | S-2331-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, PC-3, MCF7, HepG2, MEF, mouse brain, rat brain |
| Predicted Reactivity | Bb |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, AfGrMk |
Background
Merlin protein, also known as neurofibromin 2 (NF2), is a crucial tumor suppressor protein encoded by the NF2 gene. It plays a vital role in regulating cell proliferation, differentiation, and apoptosis. Merlin acts as a negative regulator of the Hippo signaling pathway, which is essential for controlling organ size and cell fate determination. When functioning normally, Merlin helps to inhibit the overgrowth of cells and prevents the formation of tumors. Mutations in the NF2 gene that lead to a loss of functional Merlin protein are associated with the development of various types of cancer, including schwannomas, meningiomas, and mesotheliomas. In addition to its role in cancer, Merlin is also involved in the regulation of cell adhesion and the maintenance of cellular architecture. Ongoing research is focused on understanding the detailed mechanisms of Merlin's action and exploring potential therapeutic strategies targeting the Merlin-Hippo pathway for cancer treatment.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy