SKU: 6360789387

FITC Human Anti-Human GM-CSF Antibody (S-2816)

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Description

FITC Human Anti-Human GM-CSF Antibody (S-2816)Product Specification Host Human Antigen GM CSF Synonyms Granulocyte macrophage colony stimulating factor; Colony stimulating factor (CSF); Molgramostin; Sargramostim; GMCSF; CSF2 Location Secreted Accession P04141 Clone Number S 2816 Antibody Type Recombinant mAb Application ICFCM Reactivity Hu Positive Sample Th1 Polarization Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1%

Product Specification


Host Human
Antigen GM-CSF
Synonyms Granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor (CSF); Molgramostin; Sargramostim; GMCSF; CSF2
Location Secreted
Accession P04141
Clone Number S-2816
Antibody Type Recombinant mAb
Application ICFCM
Reactivity Hu
Positive Sample Th1 Polarization Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
ICFCM 5μl per million cells in 100μl volume Hu

Background

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as CSF2, is a multifunctional glycoprotein cytokine that serves as a critical regulator of hematopoiesis and immune responses by binding to a specific heterodimeric receptor complex composed of an alpha chain (CD116) and a shared beta chain (CD131) on target cells. Primarily produced by activated macrophages, T cells, mast cells, endothelial cells, and fibroblasts in response to inflammatory stimuli, GM-CSF stimulates the proliferation, differentiation, survival, and functional activation of myeloid progenitor cells, driving their development into mature granulocytes (such as neutrophils, eosinophils, and basophils) and monocytes/macrophages while simultaneously enhancing the antimicrobial and antigen-presenting capabilities of these mature cells through mechanisms like increased phagocytosis, oxidative burst, and upregulation of MHC class II molecules. Beyond its physiological role in boosting host defense against infections and maintaining tissue homeostasis, GM-CSF plays a significant pathological role in chronic inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where its overproduction contributes to sustained inflammation and tissue damage, making it a prominent therapeutic target for monoclonal antibodies aimed at blocking its signaling pathway, while recombinant forms of the protein (e.g., sargramostim) are clinically utilized to accelerate myeloid recovery following chemotherapy or bone marrow transplantation.

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SKU: 6360789387

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4.4 ★★★★★
Based on 18 reviews
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Product Reviews
J
Verified Purchase
Janis E White
Omaha, US
★★★★★ 5
Perfect hole placement
Size: 11 Holes
Worked exactly as described.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 24, 2025
J
Verified Purchase
Jeffrey A Bradley
Dallas, US
★★★★★ 5
Good jig
Size: 11 Holes
The jig itself is great. The markings make it easy to be consistent; the design is well thought-out; and the build quality is good. I would recommend replacing the drill bit, though. A nice brad point will serve you better.
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Reviewed in the United States on December 5, 2025
W
Verified Purchase
WhiteTiger96
Alexandria, US
★★★★★ 5
Great
Size: 11 Holes
Worked better than expected
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Reviewed in the United States on March 10, 2026
M
Verified Purchase
Mark Danielson
Boise, US
★★★★★ 2
In the trash after a single use
Size: 11 Holes
For context, I’m a seasoned woodworker and always evaluate tools with the price in mind. This seemed like a good deal and in fact when it arrived, it looked and felt like reasonable quality for the price. Unhappily, the first bookshelf I drilled was off from side to side by almost 3 mm which would make a really wobbly shelf situation. It took a while to figure out what was happening, but I finally realized the metal bushings that guide the drill bit are so soft that they cored out from contact with the bit even though I was cautious to not put the bit in under power but to get it in the bushing and aligned before drilling. Still, the bushings started angling immediately. So when you then use those angled bushings to set the pin for the next series, it’s off by a little bit. Then the next is off by a little more…. By the time I drilled holes up and down a 6’ high shelf, the bushings were out of square, the holes were 3 mm out of alignment, and the shelf sides were firewood. Back to the drawing board and this goes in the trash, I’m afraid.
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Reviewed in the United States on May 3, 2026
B
Verified Purchase
bauhaus78
Lexington, US
★★★★★ 5
Finally, A Great Trackball for Macs
After reading the other Amazon reviews, I thought I would respond to some of the issues other reviewers raise from a Mac user's perspective. I run a new PowerBook 15" with OS X 10.3.2. Unlike some other reviewers, I didn't notice any directional/orientation problems--the cursor follows the ball movement very well, even before installing the included Logitech software. Perhaps the necessary drivers are now universally available, or perhaps the Mac version is just better. Also, the "finger layout" has not proven to be an issue for me--I can use any or all of my fingers to control the ball without any cursor-direction problems. The wireless function has proven flawless on my Mac. The reciever is a couple feet away and actually off the desk (no line of sight) and works fine. It was essentially plug-and-play on the Mac--I didn't even have to push the 'Connect' buttons to establish a signal, it just worked. The software is necessary, however, to re-assign new functions to the several buttons on this model. As a former PC user, I can't go without a right-click button (one of the reasons I bought an external device for my notebook at all). The Mac software is very easy to use, and one can re-program all of the buttons and the wheel if one so desires. You can set a button to automatically double- or triple-click, or select keyboard shortcuts (e.g., Command and W to close the current window). Very easy, and quite useful--I use buttons to close windows, quit programs, delete files, and still have a handy web-browsing 'Back' button. The only possible drawback to the Mac software is that one cannot "train" the ball's orientation (from what I can gather from other reviews, this option is not available on PC either). This really only matters if you know you hold trackballs at a different angle than most people do. Please note that the software I'm reviewing is for Mac OS X only; the program for those running OS 8.6-9.2 is a different piece of software, which is also included in the package. Those are all the Mac-specific comments I can think of at this point; if you're a Mac-user you're probably used to things "just working," and this device is no exception. I'll also comment on some of the more universal issues raised by other reviews: Ergonomically, there is a period of adjustment--anyone moving from a conventional mouse to any trackball or from one trackball to another should expect that. It's never a bad idea to try one out in-store to see how they feel, especially since trackball models vary from one to another much more than mice do. This is not, as some have termed it, a 'disadvantage'--all new things take some time to get used to. If you've never used a trackball, it's weird for a while; it's also ergonomically superior/healthier in the long term. Also, I use trackballs for computer drafting/design, and find superior control to mice--finger-control is just more precise than either thumb-controlled trackballs or wrist/arm-controlled mice. The optical ball-tracking technology requires almost no cleaning, and there are zero moving parts to clean. Just pop the ball out and blow any collected lint out of the socket if necessary--which very rarely is. For any pointing device that's wireless, optical, and has this many buttons, this price is pretty decent--lower, I think, than my previous trackball that was wired and lacked the wheel. As for Logitech's reputation/reliability, I have had good experiences. My first trackball had to be replaced during the warranty period, but its replacement has lasted the four years since--I only replaced it now because it wasn't Mac-compatible. Now Mac-users can rejoice with a high-performance trackball that works seamlessly in OS X.
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Reviewed in the United States on February 11, 2004

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