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Description
FLT-3L Protein, HumanProduct Specification Species Human Synonyms Flt3L,SL cytokine,Flt 3 Ligand,Fms related tyrosine kinase 3 ligand Accession P49771 Amino Acid Sequence Thr27 Pro185 Expression System HEK293 Molecular Weight 17 28 kDa(Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | Flt3L,SL cytokine,Flt-3 Ligand,Fms-related tyrosine kinase 3 ligand |
| Accession | P49771 |
| Amino Acid Sequence | Thr27-Pro185 |
| Expression System | HEK293 |
| Molecular Weight | 17-28 kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Fms-like tyrosine kinase 3 (FLT-3) is a cytokine receptor expressed on the surface of bone-marrow progenitor of hematopoietic cells. FLT-3 ligands (FLT-3L) are produced by peripheral blood mononuclear cells, and found in various human body fluids. FLT-3L is a cytokine that promotes the survival, proliferation, and differentiation of hematopoietic progenitors in synergy with other growth factors, such as stem cell factor. FLT-3 signal is involved in the regulation of vessel formation as well as B cell differentiation, suggesting that FLT-3 signal contributes to the pathogenesis of vascular abnormalities and immune dysregulation in rheumatic diseases. The FLT-3L plays a role in complex cytokine interactions in the process of proliferation and differentiation of various hematologic periods while it is a router in early cell interactions. The FLT-3 receptor is a transmembrane protein that reaches its biologically active form by proteolytic lysis. It was suggested that with its proliferative activity, the FLT-3L also has an antitumor effect. The FLT-3L is an earlier releaser of the progenitor cells from the stem cell pool according to GM-CSF and G-CSF actions, which occur later. Additionally, a study on mouse models showed that the FLT-3L increases the blood amount of CD34 cells. These features gave rise to the idea that recombinant FLT-3L could be used in bone marrow transplantation to evoke cell mobilization. Similarly, some authors theorized that the FLT-3L could be used in many pathological diseases such as Fanconi and aplastic anemia that originated from stem cell defects.
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